PT  - JOURNAL ARTICLE
AU  - Mahlon D. Johnson
AU  - Eli J. Rogers
AU  - Muhammad Waqas Khan
AU  - Phillip D. McMullen
AU  - Sajal Medha K Akkipeddi
AU  - Thomas Mattingly
AU  - Curtis G. Benesch
AU  - Matthew T. Bender
TI  - Carotid Intimal Sarcoma Presenting as Large Vessel Occlusion and Diagnosed by Embolus Histopathology
AID  - 10.1212/CPJ.0000000000200129
DP  - 2023 Feb 01
TA  - Neurology: Clinical Practice
PG  - e200129
VI  - 13
IP  - 1
4099  - http://cp.neurology.org/content/13/1/e200129.short
4100  - http://cp.neurology.org/content/13/1/e200129.full
AB  - Objective The objective of this study was to present the clinical, histopathologic, and radiographic findings of a unique case of intimal sarcoma (IS) embolus presenting as a large vessel occlusion causing an ischemic stroke without a detectable primary tumor site.Methods Extensive examinations, multimodal imaging, laboratory testing, and histopathologic analysis were used in evaluation.Results We report the case of a patient who presented with acute embolic ischemic stroke and was found to have IS based on a histopathologic evaluation of his embolectomy specimen. Subsequent comprehensive imaging studies failed to detect a primary tumor site. Multidisciplinary interventions including a course of radiotherapy were performed. The patient died of recurrent multifocal strokes 92 days after diagnosis.Discussion Meticulous histopathologic analysis should be conducted on cerebral embolectomy specimens. Histopathology may be useful in diagnosing IS.