RT Journal Article
SR Electronic
T1 Pediatric Moyamoya Syndrome Secondary to Tuberculous Meningitis
JF Neurology: Clinical Practice
FD Lippincott Williams & Wilkins
SP e200121
DO 10.1212/CPJ.0000000000200121
VO 13
IS 1
A1 Ari D. Kappel
A1 Laura L. Lehman
A1 Weston T. Northam
A1 Alfred P. See
A1 Edward R. Smith
YR 2023
UL http://cp.neurology.org/content/13/1/e200121.abstract
AB Objectives Tuberculosis is uncommon in the United States and a rare cause of meningitis in children with severe neurologic consequences. Tuberculous meningitis (TBM) is an even rarer cause of moyamoya syndrome with only a handful of cases previously reported.Methods We report the case of a female patient who initially presented at 6 years of age with TBM and developed moyamoya syndrome requiring revascularization surgery.Results She was found to have basilar meningeal enhancement and right basal ganglia infarcts. She was treated with 12 months of antituberculosis therapy and 12 months of enoxaparin and maintained on daily aspirin indefinitely. However, she developed recurrent headaches and transient ischemic attacks and was found to have progressive bilateral moyamoya arteriopathy. At age 11 years, she underwent bilateral pial synangiosis for the treatment of her moyamoya syndrome.Discussion Moyamoya syndrome is a rare but serious sequalae of TBM and may be more common in pediatric patients. The risk of stroke may be mitigated by pial synangiosis or other revascularization surgeries in carefully selected patients.