RT Journal Article
SR Electronic
T1 Pediatric SARS-CoV-2–Related Diplopia and Mesencephalic Abnormalities
JF Neurology: Clinical Practice
FD Lippincott Williams & Wilkins
SP e124
OP e128
DO 10.1212/CPJ.0000000000200076
VO 12
IS 5
A1 Signa, Sara
A1 Brolatti, Noemi
A1 Trincianti, Chiara
A1 Tortora, Domenico
A1 Saffioti, Carolina
A1 Di Marco, Eddi
A1 Acquila, Maura
A1 Amadori, Elisabetta
A1 Fiorillo, Chiara
A1 Ricci, Erica
A1 Striano, Pasquale
A1 Castagnola, Elio
A1 Vari, Maria Stella
YR 2022
UL http://cp.neurology.org/content/12/5/e124.abstract
AB Objective This case report describes a patient with mesencephalic MRI signal abnormality and diplopia, possibly associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Methods We describe a boy with binocular diplopia and nystagmus. The pattern of serology positivity and negative direct research of SARS-CoV-2 RNA in our patient allowed us to consider novel coronavirus as the trigger of possible immune-mediated phenomena against the central nervous system.Results During hospitalization, blood tests revealed a recent SARS-CoV-2 infection. MRI revealed hyperintensity of the mesencephalic tegmentum and periaqueductal region, consistent with an inflammatory lesion of the midbrain tegmentum. Viral and bacterial molecular screening on cerebrospinal fluid and isoelectrofocusing analysis, anti–myelin oligodendrocyte glycoprotein, anti–aquaporine-4, and anti–N-methyl-d-aspartate antibodies were negative. The patient was treated with steroids and immunoglobulin therapy with complete remission of neurologic symptoms.Discussion This report expands the spectrum of pediatric COVID-19–associated neurologic symptoms and highlights a possible isolated neurologic COVID-19–related symptom.