RT Journal Article
SR Electronic
T1 Need to Revise Frascati Criteria for HIV-Associated Neurocognitive Disorders to Improve Relevance for Diverse Global Populations
JF Neurology: Clinical Practice
FD Lippincott Williams & Wilkins
SP 328
OP 330
DO 10.1212/CPJ.0000000000200063
VO 12
IS 4
A1 Ana-Claire L. Meyer
YR 2022
UL http://cp.neurology.org/content/12/4/328.abstract
AB Worldwide, cognitive impairment is a frequent complication of HIV, and few treatments are available. Existing diagnostic criteria for cognitive disorders associated with HIV have limited diagnostic accuracy, hampering biomarker and therapeutic development. Furthermore, these criteria are not linked to clinically meaningful outcomes, limiting utility in clinical settings. Limitations in diagnostic accuracy are most pronounced in resource-limited settings where the burden of HIV is greatest, largely because of heavy reliance on neuropsychological testing with limited cross-cultural validity. Accurate and clinically meaningful diagnostic criteria validated in diverse populations will improve research and clinical care for cognitively impaired people living with HIV globally.