RT Journal Article
SR Electronic
T1 Cerebral White Matter Injury in a Newborn Infant With COVID-19
JF Neurology: Clinical Practice
FD Lippincott Williams & Wilkins
SP e22
OP e24
DO 10.1212/CPJ.0000000000001173
VO 12
IS 3
A1 Alves, Lucas
A1 Alcântara, Thaís
A1 Hazin, Adriano
A1 Lucato, Leandro
A1 Ferraz de Magalhães, Jurandy Júnior
A1 Alves, Joao
A1 Meneses, Jucille
YR 2022
UL http://cp.neurology.org/content/12/3/e22.abstract
AB Because the COVID-19 pandemic evolves, reports of neurologic manifestations and neuroimaging associated with SARS-CoV-2 have been reported in children and in neonates, although very few when compared with adults.Objectives To describe a 3-day-old neonate presenting afebrile seizures with a persistent positive nasopharyngeal swab for SARS-CoV-2 and neuroimaging demonstrating extensive cerebral white matter injury.Methods Consent was obtained to report this case. SARS-CoV-2 was tested using real-time reverse transcriptase-polymerase chain reaction amplification of virus acid from a nasopharyngeal swab. MRI of the brain was performed using axial T1, T2, fluid-attenuated inversion recovery, diffusion-weighted imaging, and T1 postcontrast sequences.Results Brain MRI showed restricted diffusion in the periventricular white matter, subcortical white matter, and splenium of the corpus callosum.Discussion Neurologic presentation of SARS-CoV-2 in newborns seems to be rare and is not fully known. SARS-CoV-2 infection should be considered in newborns with seizures and white matter abnormalities.