PT  - JOURNAL ARTICLE
AU  - Alves, Lucas
AU  - Alcântara, Thaís
AU  - Hazin, Adriano
AU  - Lucato, Leandro
AU  - Ferraz de Magalhães, Jurandy Júnior
AU  - Alves, Joao
AU  - Meneses, Jucille
TI  - Cerebral White Matter Injury in a Newborn Infant With COVID-19
AID  - 10.1212/CPJ.0000000000001173
DP  - 2022 Jun 01
TA  - Neurology: Clinical Practice
PG  - e22--e24
VI  - 12
IP  - 3
4099  - http://cp.neurology.org/content/12/3/e22.short
4100  - http://cp.neurology.org/content/12/3/e22.full
AB  - Because the COVID-19 pandemic evolves, reports of neurologic manifestations and neuroimaging associated with SARS-CoV-2 have been reported in children and in neonates, although very few when compared with adults.Objectives To describe a 3-day-old neonate presenting afebrile seizures with a persistent positive nasopharyngeal swab for SARS-CoV-2 and neuroimaging demonstrating extensive cerebral white matter injury.Methods Consent was obtained to report this case. SARS-CoV-2 was tested using real-time reverse transcriptase-polymerase chain reaction amplification of virus acid from a nasopharyngeal swab. MRI of the brain was performed using axial T1, T2, fluid-attenuated inversion recovery, diffusion-weighted imaging, and T1 postcontrast sequences.Results Brain MRI showed restricted diffusion in the periventricular white matter, subcortical white matter, and splenium of the corpus callosum.Discussion Neurologic presentation of SARS-CoV-2 in newborns seems to be rare and is not fully known. SARS-CoV-2 infection should be considered in newborns with seizures and white matter abnormalities.