RT Journal Article
SR Electronic
T1 Prevalence of Rhinorrhea in Parkinson Disease: A Systematic Review and Meta-analysis
JF Neurology: Clinical Practice
FD Lippincott Williams & Wilkins
SP 10.1212/CPJ.0000000000001180
DO 10.1212/CPJ.0000000000001180
A1 Chen, Tiffany
A1 Edwards, Thomas S
A1 Hinson, Vanessa K
A1 Soler, Zachary M
YR 2022
UL http://cp.neurology.org/content/early/2022/05/18/CPJ.0000000000001180.abstract
AB Purpose of Review: To perform a systematic review and determine prevalence of rhinorrhea in Parkinson’s Disease (PD).Recent findings: Of 451 patients with PD and 233 controls, pooled prevalence of rhinorrhea in patients with PD was 45.0% (95% CI 33.94, 56.40), significantly greater than in controls (p<0.001). Prevalence of self-reported olfactory dysfunction was greater in patients with PD; however, a pooled analysis of studies using objective scores showed no difference. Mean age of PD patients was greater than controls (p=0.002). Mean age of PD patients with rhinorrhea was also greater than PD patients without rhinorrhea (p<0.001) but disease characteristics did not differ.Summary: There is a high prevalence of rhinorrhea in patients with PD, therefore providers should query for rhinorrhea during visits and understand the treatment options available. Future studies should explore the pathophysiology of rhinorrhea in PD, the relationship between rhinorrhea and disease severity and duration, and determine whether treatment-specific outcomes differ in patients with PD