RT Journal Article SR Electronic T1 Probable Cerebral Amyloid Angiopathy–Related Inflammation Associated With Sitravatinib JF Neurology: Clinical Practice FD Lippincott Williams & Wilkins SP e4 OP e6 DO 10.1212/CPJ.0000000000001162 VO 12 IS 2 A1 Ray, Christopher A1 Dionne, Kalen YR 2022 UL http://cp.neurology.org/content/12/2/e4.abstract AB Background and Objectives We present the case of a 67-year-old man who developed encephalopathy, headaches, and seizure activity after initiating treatment with the novel tyrosine kinase inhibitor, sitravatinib.Methods The patient was identified in routine clinical practice.Results Brain MRI revealed lobar microhemorrhages and bihemispheric vasogenic edema. The patient met the criteria for probable cerebral amyloid angiopathy–related inflammation (CAA-ri) and responded favorably to high-dose methylprednisolone.Discussion This report of neurologic autoimmunity in a patient receiving sitravatinib opens new lines of inquiry into the pathophysiology of CAA-ri. We emphasize the importance of early recognition and treatment of CAA-ri among patients receiving immunomodulatory chemotherapy.