PT - JOURNAL ARTICLE AU - Glenardi, Glenardi AU - Handayani, Tutwuri AU - Barus, Jimmy AU - Mangkuliguna, Ghea TI - Inhaled Levodopa (CVT-301) for the Treatment of Parkinson Disease AID - 10.1212/CPJ.0000000000001143 DP - 2022 Apr 01 TA - Neurology: Clinical Practice PG - 139--148 VI - 12 IP - 2 4099 - http://cp.neurology.org/content/12/2/139.short 4100 - http://cp.neurology.org/content/12/2/139.full AB - Purpose of Review To investigate the efficacy and safety of CVT-301 in treating motor fluctuation in patients with Parkinson disease (PD).Recent Findings This study demonstrated that the CVT-301 group had a higher proportion of patients achieving an ON state than the placebo group (odds ratio [OR] = 2.68; 95% confidence interval [CI]: 1.86–3.86; p < 0.00001). Moreover, CVT-301 had also shown to improve motor function by Unified Parkinson Disease Rating Scale part III score (standardized mean difference = 3.83; 95% CI: 2.44–5.23; p < 0.00001) and promote an overall improvement of PD by Patient Global Impression of Change self-rating (OR = 2.95; 95% CI: 1.78–4.9; p < 0.00001). The most common adverse events encountered were respiratory symptoms (OR = 12.18; 95% CI: 5.01–29.62; p < 0.00001) and nausea (OR = 3.95; 95% CI: 1.01–15.41; p = 0.05).Summary CVT-301 had the potential to be an alternative or even a preferred treatment for motor fluctuation in patients with PD.