RT Journal Article
SR Electronic
T1 The Potentially Modifiable Risk Factor in Idiopathic Intracranial Hypertension
JF Neurology: Clinical Practice
FD Lippincott Williams & Wilkins
SP e504
OP e507
DO 10.1212/CPJ.0000000000001063
VO 11
IS 4
A1 Mollan, Susan P.
A1 Tahrani, Abd A.
A1 Sinclair, Alexandra J.
YR 2021
UL http://cp.neurology.org/content/11/4/e504.abstract
AB Purpose of Review Idiopathic intracranial hypertension (IIH) prevalence increased in conjunction with rising obesity rates. Here, we highlight the importance of weight management in IIH and introduce glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) as potential treatment strategy for IIH.Recent Findings Weight gain is a risk factor for IIH, and weight loss (via any treatment strategy) plays a key role in IIH management. GLP-1 is an incretin secreted by the distal small intestine in response to a meal. GLP-1 RAs have been shown to improve glycaemic control (no hypoglycaemia) and lower body weight in patients with and without type 2 diabetes. The choroid plexus has been found to express GLP-1 receptors, and treatment with a GLP-1 RA significantly reduces CSF secretion in vitro and intracranial pressure (ICP) in rodents.Summary New research evaluating the pathophysiology of IIH supports GLP-1 RA as a potential treatment for IIH via weight loss dependent and independent mechanism to directly reduce ICP.