RT Journal Article
SR Electronic
T1 Immediate reactions with glatiramer acetate
JF Neurology: Clinical Practice
FD Lippincott Williams & Wilkins
SP 170
OP 177
DO 10.1212/CPJ.0000000000000714
VO 10
IS 2
A1 Guadalupe Marco-Martín
A1 Pilar Tornero
A1 Alicia Prieto
A1 Alejandro La Rotta
A1 Teresa Herrero
A1 Maria Luisa Baeza
YR 2020
UL http://cp.neurology.org/content/10/2/170.abstract
AB Purpose of review Diverse adverse events have been associated with administration of glatiramer acetate (GA), mainly local reactions at the injection site. Other, less frequent generalized reactions include isolated postinjection reactions and anaphylaxis, which may lead to discontinuation of GA.Recent findings Close collaboration between the allergy and neurology departments is needed to study adverse reactions to GA. The allergy study should include a detailed history and skin prick and intradermal tests with GA and, if possible, determination of specific IgE levels. Furthermore, the implication of other drugs should be ruled out.Summary An accurate diagnosis of reactions to GA is essential if we are to confirm or rule out allergy to GA. When an allergy diagnosis is confirmed or firmly suspected based on clinical evidence, desensitization protocols are increasingly seen as safe methods for reintroduction of GA.