PT  - JOURNAL ARTICLE
AU  - Guadalupe Marco-Martín
AU  - Pilar Tornero
AU  - Alicia Prieto
AU  - Alejandro La Rotta
AU  - Teresa Herrero
AU  - Maria Luisa Baeza
TI  - Immediate reactions with glatiramer acetate
AID  - 10.1212/CPJ.0000000000000714
DP  - 2020 Apr 01
TA  - Neurology: Clinical Practice
PG  - 170--177
VI  - 10
IP  - 2
4099  - http://cp.neurology.org/content/10/2/170.short
4100  - http://cp.neurology.org/content/10/2/170.full
AB  - Purpose of review Diverse adverse events have been associated with administration of glatiramer acetate (GA), mainly local reactions at the injection site. Other, less frequent generalized reactions include isolated postinjection reactions and anaphylaxis, which may lead to discontinuation of GA.Recent findings Close collaboration between the allergy and neurology departments is needed to study adverse reactions to GA. The allergy study should include a detailed history and skin prick and intradermal tests with GA and, if possible, determination of specific IgE levels. Furthermore, the implication of other drugs should be ruled out.Summary An accurate diagnosis of reactions to GA is essential if we are to confirm or rule out allergy to GA. When an allergy diagnosis is confirmed or firmly suspected based on clinical evidence, desensitization protocols are increasingly seen as safe methods for reintroduction of GA.