SARS-CoV-2 Infection and Vaccination Outcomes in Multiple Sclerosis
Citation Manager Formats
Make Comment
See Comments

Abstract:
Background: The effects of the SARs-CoV-2 vaccination and infection on clinical outcomes, including relapse risk, have been insufficiently explored in people with MS (PwMS). The objectives of this study were to determine the incidence of new neurologic symptoms or symptom recrudescence among PwMS who received the SARs-CoV-2 vaccine, characterize outcomes following SARs-CoV-2 infection, and assess MS-specific determinants of vaccine hesitancy.
Methods: Online surveys that assessed incidence and severity of SARs-CoV-2 infection, vaccination status/type, reasons for vaccine deferral, and post-vaccination symptoms were administered to PwMS. Medical charts were reviewed for consenting respondents. Associations between infection, post-vaccination outcomes, and clinical characteristics were compared using chi-square tests, 2-sample T-tests, and adjusted logistic regression models.
Results: n=292 of 333 respondents were vaccinated, of which 58% reported post-vaccination side effects, most commonly among mRNA vaccine recipients (p=0.02), younger patients (p<0.01), and relapsing-remitting MS (p=0.03). Twelve percent endorsed recrudescence of existing MS symptoms, while 3% endorsed new neurologic symptoms post-vaccination. N=62 reported SARs-CoV-2 infection since the start of the pandemic, more frequent in younger individuals (1-year OR=0.958, 10-year OR=0.649, p<0.01). Neither DMT nor B-cell therapies specifically were associated with vaccine side effects, neurologic symptoms, or SARs-CoV-2 infection. Twenty-one percent of unvaccinated cited a desire for provider guidance prior to vaccination.
Conclusion: Our findings provide new data to suggest that among PwMS who received SARs-CoV-2 vaccination, clinical disease worsening is rare and mostly associated with symptom recrudescence, as opposed to new relapses. Post-vaccination side effects may occur more often among mRNA vaccine recipients, and in younger individuals.
- Received November 15, 2021.
- Accepted February 9, 2022.
- © 2022 American Academy of Neurology
The Nerve!: Rapid online correspondence
REQUIREMENTS
If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Dr. Daniel Friedman and Dr. Sharon Chiang
► Watch
Related Articles
- No related articles found.