Cohort Study in Parkinsonism: Delayed Transit, Accelerated Gastric Emptying, and Prodromal Dysmotility
Citation Manager Formats
Make Comment
See Comments

ABSTRACT
Objectives: To evaluate gastric emptying and colonic transit in a cohort of patients with Parkinson disease and other parkinsonism disorders, and to determine whether abnormal gut transit precedes motor-onset of parkinsonism.
Methods: Medical record review of 84 patients with parkinsonism who underwent clinically-indicated transit studies at Mayo Clinic (2001-2019); and 11 patients with transit studies who subsequently developed parkinsonism. Data are summarized as median (IQR).
Results: The 84 patients (52% female) with parkinsonism were aged 72 (66, 76) years with a disease duration of 5 (2, 8) years: Parkinson disease=70, multiple system atrophy=7, dementia with Lewy bodies=4, progressive supranuclear palsy=2, parkinsonian syndrome=1. Ten had delayed GE, 10 slow colonic transit, 16 accelerated GE (14 Parkinson disease, 1 multiple system atrophy, 1 parkinsonian syndrome), and 49 normal transit. One parkinsonian syndrome patient had both slow colonic and accelerated gastric transit. Longer disease duration and higher levodopa equivalent daily dose were observed for Parkinson disease compared to other parkinsonisms and with slow compared to normal colonic transit. Of 11 patients (5 female) with transit studies who later developed motor parkinsonism after 4 (3, 5) years: 1 had accelerated GE, 1 had delayed GE, and 1 had both delayed GE and colonic transit.
Conclusions: Accelerated GE was newly identified in patients with parkinsonism, in addition to delayed GE or colonic transit. Furthermore, gut dysmotility was objectively identified to precede the motor-onset of parkinsonism.
- Received June 8, 2020.
- Accepted September 21, 2020.
- © 2020 American Academy of Neurology
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)
Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here
Purchase
Individual access to articles is available through the Add to Cart option on the article page. Access for 1 day (from the computer you are currently using) is US$ 39.00. Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means. The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use. Distributing copies (electronic or otherwise) of the article is not allowed.
The Nerve!: Rapid online correspondence
NOTE: All contributors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.cp.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.
- Stay timely. Submit only on articles published within the last 8 weeks.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- 200 words maximum.
- 5 references maximum. Reference 1 must be the article on which you are commenting.
- 5 authors maximum. Exception: replies can include all original authors of the article.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Related Articles
- No related articles found.