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October 2019; 9 (5) Research

Functional gastrointestinal disorders negatively affect health-related quality of life in MS

Ruth Ann Marrie, Stella Leung, Tuula Tyry, Gary R. Cutter, Robert Fox, Amber Salter
First published May 24, 2019, DOI: https://doi.org/10.1212/CPJ.0000000000000668
Ruth Ann Marrie
Department of Internal Medicine (RAM), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba; Department of Community Health Sciences (RAM, SL), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Dignity Health (TT), St. Joseph's Hospital and Medical Center, Phoenix, AZ; Department of Biostatistics (GRC), University of Alabama at Birmingham, AL; Mellen Center for Multiple Sclerosis (RF), Neurological Institute, Cleveland Clinic, OH; and Department of Biostatistics (AS), Washington University in St. Louis, MO.
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Stella Leung
Department of Internal Medicine (RAM), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba; Department of Community Health Sciences (RAM, SL), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Dignity Health (TT), St. Joseph's Hospital and Medical Center, Phoenix, AZ; Department of Biostatistics (GRC), University of Alabama at Birmingham, AL; Mellen Center for Multiple Sclerosis (RF), Neurological Institute, Cleveland Clinic, OH; and Department of Biostatistics (AS), Washington University in St. Louis, MO.
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Tuula Tyry
Department of Internal Medicine (RAM), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba; Department of Community Health Sciences (RAM, SL), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Dignity Health (TT), St. Joseph's Hospital and Medical Center, Phoenix, AZ; Department of Biostatistics (GRC), University of Alabama at Birmingham, AL; Mellen Center for Multiple Sclerosis (RF), Neurological Institute, Cleveland Clinic, OH; and Department of Biostatistics (AS), Washington University in St. Louis, MO.
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Gary R. Cutter
Department of Internal Medicine (RAM), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba; Department of Community Health Sciences (RAM, SL), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Dignity Health (TT), St. Joseph's Hospital and Medical Center, Phoenix, AZ; Department of Biostatistics (GRC), University of Alabama at Birmingham, AL; Mellen Center for Multiple Sclerosis (RF), Neurological Institute, Cleveland Clinic, OH; and Department of Biostatistics (AS), Washington University in St. Louis, MO.
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Robert Fox
Department of Internal Medicine (RAM), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba; Department of Community Health Sciences (RAM, SL), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Dignity Health (TT), St. Joseph's Hospital and Medical Center, Phoenix, AZ; Department of Biostatistics (GRC), University of Alabama at Birmingham, AL; Mellen Center for Multiple Sclerosis (RF), Neurological Institute, Cleveland Clinic, OH; and Department of Biostatistics (AS), Washington University in St. Louis, MO.
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Amber Salter
Department of Internal Medicine (RAM), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba; Department of Community Health Sciences (RAM, SL), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Dignity Health (TT), St. Joseph's Hospital and Medical Center, Phoenix, AZ; Department of Biostatistics (GRC), University of Alabama at Birmingham, AL; Mellen Center for Multiple Sclerosis (RF), Neurological Institute, Cleveland Clinic, OH; and Department of Biostatistics (AS), Washington University in St. Louis, MO.
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Citation
Functional gastrointestinal disorders negatively affect health-related quality of life in MS
Ruth Ann Marrie, Stella Leung, Tuula Tyry, Gary R. Cutter, Robert Fox, Amber Salter
Neurol Clin Pract Oct 2019, 9 (5) 381-390; DOI: 10.1212/CPJ.0000000000000668

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Abstract

Objective To determine the prevalence of functional gastrointestinal disorders, the demographic and clinical characteristics associated with the presence of functional gastrointestinal disorders, and the effects of these disorders with health-related quality of life (HRQOL) in a large, diverse population of persons with MS.

Methods In 2014, we surveyed participants in the North American Research Committee on Multiple Sclerosis registry regarding functional gastrointestinal disorders using the Rome III questionnaire. Participants also reported their sociodemographic characteristics, disability status using Patient Determined Disease Steps, the presence of comorbid depression and anxiety, health behaviors, and HRQOL using the RAND-12. We determined the prevalence of each gastrointestinal disorder using the Rome III criteria. Using multivariable logistic regression models, we assessed the factors associated with the presence of each bowel disorder. Using linear regression, we evaluated the association between functional gastrointestinal disorders and HRQOL.

Results Of 6,312 eligible respondents, 76.5% were female, with a mean (SD) age of 58.3 (10.2) years. Forty-two percent of respondents (n = 2,647) had a functional gastrointestinal disorder, most often irritable bowel syndrome (IBS), which affected 28.2% of participants. The prevalence of all functional gastrointestinal disorders increased with greater disability, and the prevalence of IBS increased with longer disease duration. After adjusting for sociodemographic and clinical characteristics, functional gastrointestinal disorders were associated with lower physical and mental HRQOL (both p < 0.0001).

Conclusions Functional gastrointestinal disorders are common in MS and are associated with reduced HRQOL.

Footnotes

  • Funding information and disclosures are provided at the end of the article. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp.

  • Received December 30, 2018.
  • Accepted February 12, 2019.
  • © 2019 American Academy of Neurology
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