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April 2019; 9 (2) Research

Predictors of dementia misclassification when using brief cognitive assessments

Janice M. Ranson, Elżbieta Kuźma, William Hamilton, Graciela Muniz-Terrera, Kenneth M. Langa, David J. Llewellyn
First published November 28, 2018, DOI: https://doi.org/10.1212/CPJ.0000000000000566
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Article Information

vol. 9 no. 2 109-117
DOI: 
https://doi.org/10.1212/CPJ.0000000000000566
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
2163-0402
Online ISSN: 
2163-0933
History: 
  • Received May 30, 2018
  • Accepted September 17, 2018
  • First Published November 28, 2018.

Article Versions

Copyright & Usage: 
© 2018 American Academy of Neurology

Author Disclosures

    1. Janice M. Ranson, MSc,
    2. Elżbieta Kuźma, PhD,
    3. William Hamilton, MD,
    4. Graciela Muniz-Terrera, PhD,
    5. Kenneth M. Langa, MD, PhD and
    6. David J. Llewellyn, PhD
  1. Janice M. Ranson, MSc,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Elżbieta Kuźma, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1)Halpin Trust(2) James Tudor Foundation(3) Wellcome Trust ISSF Seed Corn Fund(4) Mary Kinross Charitable Trust

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. William Hamilton, MD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Family Practice (Oxford), Associate Editor, since 2007

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. Policy Research Unit in Cancer Awareness, Screening and Early Diagnosis, Department of Health. ?4,997,576.00 [co- applicant, and early diagnosis lead] 2018-2023. 2.Understanding the effectiveness, cost-effectiveness and current use of cancer diagnostic tools to aid decision- making in primary care. HTA ?240,800. [co-applicant] 2017-8 3. 'WICKED? (Wales Interventions and Cancer Knowledge about Early Diagnosis): The development and evaluation of primary care interventions to expedite the diagnosis of symptomatic cancer in Wales. Welsh Govt ?800,000, 2016-8. [co-applicant] 4. Clinical and cost effectiveness of progressive exercise compared to best practice advice, with or without corticosteroid injection, for the treatment of rotator cuff disorders: a 2x2 factorial randomized controlled trial (GRASP). NIHR HTA ?1,228,000 2016-9.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1. What is the clinical-effectiveness and cost-effectiveness of embedded risk-of-cancer assessment of patients in primary care; the ERICA trial. W Hamilton, M Pitt, Anne Spencer, John Campbell, Rod Taylor, G Abel & F Warren, and S Dean. ?2.75m Philanthropic donation to University of Exeter, D and M Gillings, 2018-2020 [principal applicant] 2.Selection of Eligible People for Lung Cancer Screening using Electronic Primary Care DaTa: Development of new risk prediction models. Baldwin, D, O?Dowd, E, Hubbard, R, de Koning, H, Field, J, Hamilton, W, Callister, M, ten Haaf, K, Janes, S. CRUK. 2018-2021, ?352,945. [co-applicant] 3. Enhancing the diagnostic pathway for dementia: The DECODE Project. Llewellyn D,Ballard, C, Campbell, J, Hamilton W, Dean D, Kuzma, E, Moore, S, Warren, F, Lang I. The Halpin Trust. ?123,558. 2018-2020. 4. Guideline discordant diagnostic care: when do primary care referrals not reflect guidelines for suspected cancer. Abel G, Lyratzopoulos, G, Campbell, J, Hamilton W. CRUK, ?117.089. 2018-9. [co-applicant] 5. CanTest- Cancer diagnostic testing in primary care: a paradigm shift for cancer diagnosis. Hamilton W, Walter F (co-PIs), Johnson, M, Singh, H, Lyratzopoulos, G, Abel, G, Spencer, A, Thompson, M, Sutton, S, Rubin, G, Neal R, Vedsted, P, Emery J. CRUK Catalyst Award, ?4,834,829. 2017- 22. [co-PI]

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Graciela Muniz-Terrera, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Kenneth M. Langa, MD, PhD and
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. University of Pennsylvania, honorarium for lecture

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIA U01 AG009740, Co-I, 2007-2018;

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. David J. Llewellyn, PhD
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) Roche, conference travel, (2) DSM, workshop travel and speaker honorarium.

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Mary Kinross Charitable Trust, (2) Alzheimer?s Society, (3) U.S. National Institute on Aging, (4) Wellcome Trust Institutional Strategic Support Award (internal), (5) Health Foundation, (6) Halpin Trust, (7) James Tudor Foundation, (8) National Institute on Aging (R01 AG055654-01A1), (9) JP Moulton Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the University of Exeter Medical School (J.M.R., E.K., W.H., D.J.L.); Centre for Dementia Prevention, University of Edinburgh (G.M.-T.), United Kingdom; The Alan Turing Institute (D.J.L.), London, United Kingdom; and Medical School (K.M.L.), Institute for Social Research, Institute for Healthcare Policy and Innovation, Veterans Affairs Ann Arbor Healthcare System, University of Michigan.
  1. Correspondence
    Dr. Llewellyn david.llewellyn{at}exeter.ac.uk
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