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April 2018; 8 (2) Review

SSRI-associated bruxism

A systematic review of published case reports

Andrew R. Garrett, Jason S. Hawley
First published March 14, 2018, DOI: https://doi.org/10.1212/CPJ.0000000000000433
Andrew R. Garrett
Department of Neurology, Walter Reed National Military Medical Center, Bethesda, MD.
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Jason S. Hawley
Department of Neurology, Walter Reed National Military Medical Center, Bethesda, MD.
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SSRI-associated bruxism
A systematic review of published case reports
Andrew R. Garrett, Jason S. Hawley
Neurol Clin Pract Apr 2018, 8 (2) 135-141; DOI: 10.1212/CPJ.0000000000000433

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Abstract

Purpose of review Antidepressant-associated movement disorders are a well-described phenomenon. However, antidepressant-associated bruxism, jaw pain, or jaw spasm, while reported in dental literature, is less commonly recognized among neurologists. We summarize the clinical features and treatment of antidepressant-associated bruxism and associated jaw pain through a systematic review of case reports.

Recent findings Antidepressant-associated bruxism may occur in pediatric and adult patients, most commonly among female patients. Patients may develop symptoms with short-term and long-term antidepressant use. Fluoxetine, sertraline, and venlafaxine were the most commonly reported offending agents. Symptoms may begin within 3–4 weeks of medication initiation and may resolve within 3–4 weeks of drug discontinuation, addition of buspirone, or substitution with another pharmacologic agent. The incidence of this phenomenon is unknown.

Summary Bruxism associated with antidepressant use is an underrecognized phenomenon among neurologists, and may be treated with the addition of buspirone, dose modification, or medication discontinuation.

Footnotes

  • Funding information and disclosures are provided at the end of the article. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp.

  • The views expressed in manuscript are those of the authors alone, and do not necessarily reflect the views of the US Department of Defense or Federal Government.

  • Received August 25, 2017.
  • Accepted December 27, 2017.
  • © 2018 American Academy of Neurology
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