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We report on a 70-year-old right-handed woman who presented with an 11-year history of a gradually progressive motor and cognitive-behavioral syndrome caused by focal cerebral β-amyloid angiopathy manifesting as discrete mass lesions. At age 59, she developed left leg clumsiness and cramping, evolving within a year into leg stiffness. Similar symptoms gradually affected her left arm. At age 65, she noted progressive word-finding difficulties, anxiety, mental rigidity, and compulsive traits. By age 68, she had difficulties with processing speed, planning, and navigation. Her history was notable for mild hypertension, hyperlipidemia, hypothyroidism, sleep apnea, bilateral carpal tunnel syndrome, and uterine fibroids; her mother had late-onset parkinsonism. She never smoked or used illicit drugs.
Footnotes
Funding information and disclosures are provided at the end of the article. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp.
- Received December 9, 2016.
- Accepted February 3, 2017.
- © 2017 American Academy of Neurology
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