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August 2017; 7 (4) Research

Frequency, determinants, and effects of early seizures after thrombolysis for acute ischemic stroke

The ENCHANTED trial

Ying Xu, Maree L. Hackett, John Chalmers, Richard I. Lindley, Xia Wang, Qiang Li, Thompson Robinson, Hisatomi Arima, Pablo M. Lavados, Craig S. Anderson, For the ENCHANTED Study Group
First published July 19, 2017, DOI: https://doi.org/10.1212/CPJ.0000000000000384
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Article Information

vol. 7 no. 4 324-332
DOI: 
https://doi.org/10.1212/CPJ.0000000000000384
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
2163-0402
Online ISSN: 
2163-0933
History: 
  • Received April 12, 2017
  • Accepted May 30, 2017
  • First Published July 19, 2017.

Article Versions

Copyright & Usage: 
© 2017 American Academy of Neurology

Author Disclosures

    1. Ying Xu, MD,
    2. Maree L. Hackett, PhD,
    3. John Chalmers, MD, PhD,
    4. Richard I. Lindley, MD,
    5. Xia Wang, PhD,
    6. Qiang Li, MBiostat,
    7. Thompson Robinson, MD,
    8. Hisatomi Arima, MD, PhD,
    9. Pablo M. Lavados, MD,
    10. Craig S. Anderson, MD, PhD,
    11. For the ENCHANTED Study Group
  1. Ying Xu, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Maree L. Hackett, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Boehringer Ingelheim, reimbursement for travel expenses

    Editorial Boards:

    1. Cochrane Stroke Group, Associate Editor, 2 years Cochrane Stroke Group, Editorial Board Member, 7 years

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. National Heart Foundation, Future Leader Fellowship 2014- 2017, Level 2 #100034

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Google

    Research Support, Government Entities:

    1. National Health and Medical Research Council, Australia Swedish Research Council Framework, Sweden National Institute for Health Research, United Kingdom

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. National Heart Foundation, Australia Cochrane Chest, Heart and Stroke, Scotland

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. John Chalmers, MD, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Research grants from Servier for the ADVANCE-ON post trial follow-up study and, and honoraria and travel support from Servier, for speaking about the ADVANCE and ADVANCE-ON studies at Scientific meetings

    Editorial Boards:

    1. Associate Editor for the Journal of Hypertension, from 2011

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. The National Health and Medical Research Council of Australia has awarded me two project grants (1) as Co- Chief Investigator for INTERACT2 for 2008-2011 : Grant number 512402:2008-2011, and (2) as Co-Chief Investigator for ENCHANTED for 2012-17 : Grant Number APP1020462.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Richard I. Lindley, MD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Honoraria for lectures for Pfizer and Covidien.

    Editorial Boards:

    1. I am an Associate Editor for the Australasian Journal on Ageing, not compensated.

    Patents:

    1. NONE

    Publishing Royalties:

    1. Stroke: The Facts. Lindley RI. Oxford University Press 2008. ISBN 978-0-19-921272-9 2nd Edition, 2017, ISBN 978-0-19-877818-9 Understanding Stroke. Lindley RI. The British Medical Association Family Doctor Series. ISBN: 1 898205 60 4. Published by Family Doctor Publications Ltd in association with the British Medical Association 2000. Second edition 2002. Third Edition 2003. Fourth edition 2005.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1) INTERACT: a randomised trial of intensive blood pressure lowering in acute intracerebral haemorrhage. Anderson C, Chalmers J, Wang J, Lindley R. 2) NHMRC (Australia) Project Grant 512402;Chief Investigator 2008-11. 3) NHMRC (Australia) Partnership Grant 569328, Chief Investigator, 2010-2014. 4) NHMRC (Australia) Project Grant APP1004170, Chief Investigator 2011-13. 5) NHMRC (Australia) Project Grant, APP1020462 Chief Investigator, 2012-2015 6) NHMRC (Australia) Project Grant, APP1024440, Chief Investigator, 2012-14 7) NHMRC (Australia) Project Grant, APP1041401, Chief Investigator 2013-6 8) NHMRC (Australia) Project Grant. APP1045391 Chief Investigator, 2013-6 9) NHMRC (Australia) Project Grant,APP1063751 Chief Investigator, 2014-6 10) NHMRC (Australia) Project Grant, APP1101113 Chief Investigator, 2016-8

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Xia Wang, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Qiang Li, MBiostat,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Thompson Robinson, MD,
    8. Scientific Advisory Boards:

    1. Advisory Board fees from Bayer and Daiichi Sankyo

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Speaker fees from Bayer and Boehringer Ingelheim

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Stroke Association

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Hisatomi Arima, MD, PhD,
    9. Scientific Advisory Boards:

    1. Kyowa Kirin Pharma

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Journal of Hypertension, Editorial Board Member, 2 year, (2) BMC Public Health, Associate Editor, 4 years, (3) Journal of Epidemiology, Associate Editor, 1 year

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. Takeda, Daiichi Sankyo, Asuka, Bayer

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NHMRC Project Grant, 1020462, Chief Investigator, 2012- 2016

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Pablo M. Lavados, MD,
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. 1. Bayer: Received travel grant by Bayer for the ?andu study. 2. Received speaker honoraria from Bayer

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. 1. Clinica Alemana, Universidad del Desarrollo: Receives institutional support from Clinica Alemana, Universidad del Desarrollo to perform stroke administration and research.

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 1. Boerhinger Ingelheim: Receives research funding for the ?andu study. 2. Astra Zeneca: Served as national leader of SOCRATES study and receives research funding for this. 3. Bayer: Serves as the National leader of the NAVIGATE ESUS trial.

    Research Support, Government Entities:

    1. CONICYT: Recieved research grant for the ?andu proyect.

    Research Support, Academic Entities:

    1. 1. Clinica Alemana-Universiad del Desarrollo: Receives academic research support from Cl?nica Alemana for the HEADPOST studies. 2. The George Institute for Global Health. Receives academic research support from TGI for the INTERACT2, ENCHANTED and HEADPOST studies.

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Craig S. Anderson, MD, PhD,
    11. Scientific Advisory Boards:

    1. Astra Zeneca and Medtronic

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Receives honoraria and for travel from Takeda China and Boehringer Ingelheim

    Editorial Boards:

    1. Stroke, Cerebrovascular Diseases, International Journal of Stroke

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Program grant (1052555), Project grant (1020462) and Fellowship (1081356) support from the National Health and Medical Research Council (NHMRC) of Australia.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. For the ENCHANTED Study Group
    1. The George Institute for Global Health (YX, MLH, JC, RIL, XW, QL, HA, CSA), University of New South Wales; Sydney Medical School (YX, MLH, JC, RIL, CSA), the University of Sydney, Australia; Department of Cardiovascular Sciences and NIHR Biomedical Research Unit for Cardiovascular Diseases (TR), University of Leicester, UK; Department of Preventive Medicine and Public Health (HA), Faculty of Medicine, Fukuoka University, Japan; Clinica Alemana de Santiago, Facultad de Medicina (PML), Clinica Alemana Universidad del Desarrollo; Departamento de Ciencias Neurológicas (PML), Facultad de Medicina, Universidad de Chile, Santiago; Neurology Department (CSA), Royal Prince Alfred Hospital, Sydney, Australia; and The George Institute China at Peking University Health Science Center (CSA), Beijing PR China.
    1. Correspondence to:
      canderson{at}georgeinstitute.org.cn
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