Quantitative EEG in attention-deficit/hyperactivity disorder

American Academy of Neurology practice and advisory findings

The American Academy of Neurology (AAN) assessment¹ found a relative lack of support for the use of TBR tests for the diagnosis of ADHD. The 3 conclusions from that assessment are as follows:

• Clinicians should inform patients with suspected ADHD and their families that the combination of TBR and frontal EEG beta power should not replace a standard clinical evaluation.

• There is a risk for substantial harm to patients misdiagnosed with ADHD, given the high false-positive diagnostic rate of TBR and frontal EEG beta power.

• Clinicians should inform patients with suspected ADHD and their families that the TBR should be used neither to confirm an ADHD diagnosis nor to support further testing after a clinical evaluation, unless such diagnostic assessments take place within the limits of a research study.

Although some studies showed that TBR has a relatively high sensitivity and specificity for ADHD, the published literature was inconclusive.

For example, one large recent study² based TBR measurements on 60 seconds of EEG. The gold standard for ADHD was unusual or unclear because patients with the most ADHD symptoms constituted the “ADHD-negative” control group. All patients were children referred to a specialized center for assessment of ADHD. Those considered to have a primary diagnosis of an anxiety, anger, or another disorder along with ADHD as a secondary diagnosis were considered ADHD-negative for this study, a classification that seemed peculiar because otherwise these patients would have been considered ADHD-positive patients. The classification decision ultimately compromised the gold standard in the study. There was no comparison to other childhood psychiatric or neurologic disorders as controls, and there were no normal controls. The diagnoses for the study were established upon initial referral, not upon follow-up, and the eventual diagnosis was unknown. The cutoff for “abnormal” was set at 1.5 SDs above the mean for age, so that 15% of the normal population would be expected by chance alone to be falsely positive. The authors were involved with commercialization of this product, which could be viewed as a conflict of interest. It seems wise to wait for further studies from investigators who do not have a commercial conflict of interest, who could run a study with a better gold standard, and in which other disorders and normal controls could be assessed.

Uncertainties abound. Increased theta is a well-known, nonspecific EEG finding common to a wide variety of conditions. Many pathologic conditions cause excess central theta, and even simple drowsiness does so. EEG is subject to normal variant rhythms that are well-known to have no pathologic implications, including benign temporal theta or its central analog the Ciganek rhythm. Temporal theta could show up in these Cz channels because the ear reference electrodes are active and will detect temporal rhythms. For all these reasons, increased central theta or TBR is a suspect sign on which to base a diagnosis of ADHD.

Background about ADHD and the TBR

Increased central theta in children with behavioral disorders was reported in the 1930s.³ Studies in the 1960s and 1970s confirmed excess theta activity in some childhood behavioral disorders.⁴ The push to use a TBR as a diagnostic test began more than 15 years ago. Initial studies⁵ described good sensitivity, specificity, and reliability for TBR as a diagnostic tool. TBR in children correlated with behavioral measures of impulsivity and inhibition both in ADHD and normal children.⁶ TBR findings in adults correlated with response times that were used as a marker for attention.⁷

However, problems began to appear with the accuracy of TBR when attempted as a diagnostic test. Attempts to reproduce earlier studies found only a 63% sensitivity and 58% specificity and even worse diagnostic accuracies for TBR in diagnosis of ADHD.^8,-,10 The TBR has a dramatic age effect, decreasing markedly as a child ages from childhood toward adulthood.¹⁰ TBR results differed depending on whether the child had hyperactive or inattentive subtype.

One study evaluated TBR correlation with ADHD symptoms in 562 patients and 309 control subjects.¹¹ Results showed a correlation of r = 0.10 for children and r = −0.14 for adults, specifically a low correlation for younger children, poor correlation for adolescents, and the inverse correlation for adults.

TBR diagnostic effect size decreased corresponding to the year of a study's publication.¹² The report showed that the enthusiasm of a notable TBR effect by initial investigators was tempered by a lack of confirmation in follow-up studies, so that the effect size decreased in proportion to the calendar year in which the study was published. Original studies showed an effect, and more recent studies failed to confirm such a distinct TBR diagnostic effect (figure).

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Figure Meta-analysis of 9 studies of patients with attention-deficit/hyperactivity disorder (ADHD) vs controls

Two age groups are presented: younger children (age 6–13; A) and all children (age 6–18; B). Theta/beta ratio (TBR) means and SDs are presented. The 9 studies are shown chronologically as published. Note how the differences between ADHD and controls narrowed over time, and how much scatter is seen in TBR measurements among studies of younger children. From Arns et al.¹²

Overall, these results suggest several conclusions: TBR may be increased in some children with ADHD. This effect may be seen only in one or another subtype (e.g., inattentive). The effect may disappear in older children and adolescents. The effect may actually be reversed in adults. TBR may not differentiate well between ADHD and normal controls, depending on which study is consulted. The effect in other disorders is unknown. The effect with drowsiness and medications is uncertain. False-positive and false-negative results may be common.

Clinical lessons

The AAN Guideline recommends that the TBR test is not yet ready for routine clinical use. Rather, it is best used in formal structured research investigations that may better define its role, if any. A similar recommendation was reached by a group of psychology QEEG experts.¹³ That group considered that TBR cannot be used to diagnose or rule out ADHD, and it does not replace a regular clinical examination.

Payers have taken a similar position (table). They consider the use of any QEEG for ADHD investigational or experimental.

The Food and Drug Administration,¹⁴ while giving its approval for commercial marketing, cautioned that TBR must be used only upon a physician's order, by a medical professional qualified and experienced to diagnose ADHD, only after a traditional evaluation, and not as a stand-alone test. It cannot be used if a routine EEG has shown any abnormalities, or if the patient has a history of seizures, or is on any seizure medication. Then a low TBR value would suggest that the clinician should check for other disorders that might have produced the patient's symptoms.

The clinician should exercise caution in use and interpretation of TBR results. Meanwhile, we await further research by investigators who are not affiliated with companies marketing these services and devices.