Neuroimaging of first-ever seizure: Contribution of MRI if CT is normalAuthors Respond:
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I read with interest the study by Ho et al.1 on the contribution of MRI scan in the diagnostic management of first-ever seizure. Standard MRI may fail to detect potential focal epileptogenic lesions and thus MRI using a dedicated epilepsy protocol such as that performed at epilepsy surgery centers is recommended nowadays.2 That it is superior to CT scan to detect potential epileptogenic lesions is well-established and the Ho et al. study attests to this. However, one should not forget a few situations such as a calcified neurocysticercosis lesion where a CT scan may have superior sensitivity for lesion detection.3 When a potential epileptogenic lesion is detected on MRI, whether it is the culprit lesion or an incidental finding needs to be determined, for patients can harbor dual pathologies such as mesial temporal sclerosis and focal cortical dysplasia.4 With rapid advances occurring in MRI technology, we can soon expect to have higher resolution MRI scans with more sensitive imaging protocols. The Ho et al. study helps reinforce the importance of EEG in the “neuroimaging” of first-ever seizure. Concordance of EEG and MRI findings is paramount for establishing the true epileptogenic potential of the lesion.
Disclosures
N. Sethi serves as Associate Editor for The Eastern Journal of Medicine.
- © 2014 American Academy of Neurology
Authors Respond:
We thank Dr. Sethi for his comments.
Disclosures
K. Ho reports no disclosures. N. Lawn has received funding for travel from UCB Pharma and research support from UCB Pharma and from the Royal Perth Hospital Medical Research Foundation. M. Bynevelt and J. Lee report no disclosures. J. Dunne has received funding for travel from UCB Pharma and from several nonprofit organizations.
References
- 1.↵
- Ho K,
- Lawn N,
- Bynevelt M,
- Lee J,
- Dunne J
- 2.↵
- Von Oertzen J,
- Urbach H,
- Jungbluth S,
- et al
- 3.↵
- 4.↵
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