Standard strategies for diagnosis and treatment of patients with newly diagnosed Parkinson disease
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In Japan, diagnosis of Parkinson disease (PD) is based on the United Kingdom PD brain bank criteria,1 including comprehensive physical examination and additional ancillary investigation, routinely a cerebral MRI. 99mTc hexamethyl-propyleneamine oxime SPECT analysis is optional with attending neurologists. Striatal dopamine transporter binding measured using β-carboxymethyoxy-3-β-(4-iodophenyl) tropane (CIT) SPECT is not available on a practical basis. Instead, an examination using 123I-metaiodobenzylguanidine myocardial scintigraphy has been available even at local hospitals, which is useful in differentiating PD from parkinsonian variants with high sensitivity and specificity.2
Footnotes
Study funding: No targeted funding reported.
Disclosures: S-i. Kubo, T. Hatano, and G. Oyama report no disclosures. N. Hattori serves on the editorial boards of Movement Disorders and the Journal of Neural Transmission. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp.
- © 2013 American Academy of Neurology
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