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October 2013; 3 (5) Clinical and Ethical Challenges

Hydration status substantially affects chronic cerebrospinal venous insufficiency assessments

Claudiu I. Diaconu, Robert J. Fox, Alia Grattan, Alexander Rae-Grant, Mei Lu, Heather L. Gornik, Esther Soo H. Kim
First published October 3, 2013, DOI: https://doi.org/10.1212/CPJ.0b013e3182a78f15
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Article Information

vol. 3 no. 5 386-391
DOI: 
https://doi.org/10.1212/CPJ.0b013e3182a78f15
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
2163-0402
Online ISSN: 
2163-0933
History: 
  • First Published October 3, 2013.

Article Versions

Copyright & Usage: 
© 2013 American Academy of Neurology

Author Disclosures

    1. Claudiu I. Diaconu, BS,
    2. Robert J. Fox, MD,
    3. Alia Grattan, RVT,
    4. Alexander Rae-Grant, MD,
    5. Mei Lu, MD, PhD,
    6. Heather L. Gornik, MD, MPH, RPVI and
    7. Esther Soo H. Kim, MD, MPH, RPVI
  1. Claudiu I. Diaconu, BS,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Robert J. Fox, MD,
    3. Scientific Advisory Boards:

    1. Biogen Idec, Novartis

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editorial Board, Neurology Editorial Board, Multiple Sclerosis Journal

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Allozyne, Avanir, Biogen Idec, Novartis, Questcor, EMD Serono, and Teva Neurosciences.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Research grant from Novartis.

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. National MS Society, RG 3548A2, 2004-2009; RG 4091A3/1 2009-2012; RG 4103A4/2, 2009-2011; RC 1004-A-5, 2010- 2012.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Alia Grattan, RVT,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Alexander Rae-Grant, MD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Biogen Idec, speaker honorarium. Teva Neurosciences, speaker honorarium, Avanir, Speaker honorarium, Novartis, Speaker honorarium

    Editorial Boards:

    1. Neurology, Evidence Review Team, 2011-2013

    Patents:

    1. NONE

    Publishing Royalties:

    1. Handbook of Multiple Sclerosis, Springer Healthcare, 2010, Comprehensive review of clinical neurology, Wolters Kluwer, 2012, 5 minute consult in neurology, Wolters Klower, 2012

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. Biogen IDEC

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. CO-PI 4% effort FMRI as an imaging biomarker for preclinical Alzheimer's disease NIH grant #A6022304, 5/15/10-4/30/15

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Co-PI: A Multi-Modal Assessment of Chronic Cerebrospinal Venous Insufficiency, National MS Society (RC 1004-A-5), 5% effort, 7/1/10 - 6/30/12

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Mei Lu, MD, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. National MS Society grant RC1004-A-5, 2010-2012,

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Heather L. Gornik, MD, MPH, RPVI and
    7. Scientific Advisory Boards:

    1. Non Profit, Roy Greenberg IDE Internal DSMB

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Vascular Medicine; (2) Current Treatment Options in Cardiovascular Medicine

    Patents:

    1. 1. Non-invasive diagnosis of lower extremity peripheral artery disease by oscillometric means. 2. Remote monitoring of anticoagulation

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Cleveland Clinic

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Medical Director, Non Invasive Vascular Laboratory, Cleveland Clinic

    Research Support, Commercial Entities:

    1. Research funding for studies related to peripheral artery disease. Theravasc, Astra-Zeneca.

    Research Support, Government Entities:

    1. Research funding for ATTRACT DVT Trial --- NHLBI via Wash U St. Louis

    Research Support, Academic Entities:

    1. Research funding for ATTRACT DVT Trial --- NHLBI via Wash U St. Louis

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License fee payments, Technology or Inventions:

    1. For patent related to non-invasive diagnosis of lower extremity peripheral artery disease by non invasive means

    Royalty Payments, Technology or Inventions:

    1. For patent related to remote monitoring of anticoagulation

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Esther Soo H. Kim, MD, MPH, RPVI
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Philips ultrasound - educational consultant

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. (1) GE - grant support: provides contrast for one of my ultrasound studies

    Clinical Procedures or Imaging Studies:

    1. Cleveland Clinic Non-Invasive Vascular Laboratory, vascular ultrasound, 15% effort, reader in the lab since 2008

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Multiple Sclerosis Society

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CID), Mellen Center for Multiple Sclerosis Treatment and Research (RJF, AR-G), Heart and Vascular Institute, Cardiovascular Medicine, Non-Invasive Vascular Laboratory (AG, HLG, ESHK), and Neurological Institute, Cerebrovascular Center (ML), Cleveland Clinic, Cleveland, OH.
  1. Correspondence to:
    kims{at}ccf.org
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Article usage: October 2013 to June 2021

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