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October 2023; 13 (5) Editorial

Reversibility of Tumor-like Lesions

Meticulous Diagnosis for Treatable Brain Diseases

View ORCID ProfileSung-Tsang Hsieh
First published August 30, 2023, DOI: https://doi.org/10.1212/CPJ.0000000000200183
Sung-Tsang Hsieh
Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
PhD
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Reversibility of Tumor-like Lesions
Meticulous Diagnosis for Treatable Brain Diseases
Sung-Tsang Hsieh
Neurol Clin Pract Oct 2023, 13 (5) e200183; DOI: 10.1212/CPJ.0000000000200183

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Tumor-like or mass lesions on brain images are one the most challenging diagnostic tasks in clinical management for neurologists. With imaging characteristics of contrast enhancement with cystic lesions, malignant glioma or infection is on the top of the diagnostic list according to neurology and radiology textbook dogma. How often does a non-neoplastic lesion become the final diagnosis? Are there any characteristics to differentiate a non-neoplastic lesion from a neoplastic one? Can any specific approach help to facilitate a correct diagnosis? These questions often emerge in daily practice. In this issue of Neurology® Clinical Practice, Perez Giraldo et al.1 summarize 10 patients with tumor-like lesions on brain images with ultimate diagnoses of demyelinating disease, inflammation (autoimmune encephalitis, granulomatous disease, vasculitis, plasma cell disorder), and infections after extensive workup. This study demonstrates and highlights the importance of integrating brain biopsy and pathologic examination to reach a correct diagnosis leading to appropriate treatment.

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  • Funding information and disclosures are provided at the end of the article. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp.

  • See page 200182

  • © 2023 American Academy of Neurology
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