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April 2023; 13 (2) Research Article

Cenobamate in Generalized Epilepsy and Combined Generalized and Focal Epilepsy

Shruti Agashe, Gregory Worrell, Jeffrey Britton, Katherine Noe, Anthony Ritaccio, Elaine C. Wirrell, Katherine C. Nickels, Gregory D. Cascino, David Burkholder
First published February 15, 2023, DOI: https://doi.org/10.1212/CPJ.0000000000200133
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Article Information

vol. 13 no. 2 e200133
DOI: 
https://doi.org/10.1212/CPJ.0000000000200133
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
2163-0402
Online ISSN: 
2163-0933
History: 
  • Received July 29, 2022
  • Accepted November 17, 2022
  • First Published February 15, 2023.
Copyright & Usage: 
© 2023 American Academy of Neurology

Author Disclosures

    1. Shruti Agashe, MD*,
    2. Gregory Worrell, MD, PhD,
    3. Jeffrey Britton, MD,
    4. Katherine Noe, MD, PhD,
    5. Anthony Ritaccio, MD,
    6. Elaine C. Wirrell, MD, FRCP(C),
    7. Katherine C. Nickels, MD,
    8. Gregory D. Cascino, MD and
    9. David Burkholder, MD*
  1. Shruti Agashe, MD*,
    2. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Gregory Worrell, MD, PhD,
    3. Scientific Advisory Boards:

    1. Cadence NeuroscienceNeuroOne Inc.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. 2. Non-profit: American Epilepsy Society. Travel expense 2022 meeting

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. Department of Neurology, Mayo Clinic, Rochester, MN 20%

    Research Support, Commercial Entities:

    1. Medtronic: received RC+S devices for NIH research

    Research Support, Government Entities:

    1. Current Support1) NIH UH3NS095495-01 Worrell, G (PI)Grant Title: Neurophysiologically Based Brain State Tracking & Modulation in Focal Epilepsy
The goal of this project is to develop an epilepsy management and therapy platform using Medtronic's 3rd generation RC+S implantable device.
2) NIH R01NS092882-01 Worrell, G (PI)07/01/2015-06/30/2020 2.4 calendarGrant Title: Reliable Seizure Prediction Using Physiological Signals and Machine Learning. The focus of this research is to develop real-time seizure forecasting in canines with epilepsy.3) EU St. Anne’s Collaboration Somers, V (PI) & Worrell, GA (Co-I) 01/01/2011 - 12/31/20150.4 calendarGrant Title: Novel Diagnostic & Therapeutic Strategies for Epilepsy and Parkinson Diseases.The goal is development of a multi-scale EEG recording and analysis platform to optimally probe cerebral cortex across the relevant spatiotemporal scale and ultimately provide classification of epileptogenic and normal brain tissue.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NeuroOne Inc, Stock recieved

    License Fee Payments, Technology or Inventions:

    1. Electrode and electrophysiology know how, NeuroOne Inc,Brain stimulation know how, Cadence Neuroscience Inc.

    Royalty Payments, Technology or Inventions:

    1. Human electrodes, NeuroOne Inc.Brain stimulation devices, Cadence Neuroscience Inc.

    Stock/Stock Options, Research Sponsor:

    1. NeuroOne Inc. 2017Cadence Neuroscience 2017

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Jeffrey Britton, MD,
    4. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. Unpaid co-investigator clinical trials: -A Randomized Double Blind Placebo Controlled Study of IVIG in Patients with Voltage Gated Potassium Channel Complex Antibody Associated Autoimmune Epilepsy - Grifols Pharmaceuticals-A double-blind, randomized, placebo-controlled study to investigate the efficacy and safety of cannabidiol (GWP42003-P, CBD) as add-on therapy in patients with tuberous sclerosis complex who experience inadequately-controlled seizures- Greenwich Pharmaceuticals- An open label extension study to investigate the safety of cannabidiol (GWP42003-P; CBD) in children and adults with inadequately controlled Dravet or Lennox-Gastaut Syndromes - Greenwich Pharmaceuticals

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Mr. and Mrs. David Hawk charitable gift for epilepsy research

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. SEER Medical - inventor agreement established 2022 - no royalties received to date

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Katherine Noe, MD, PhD,
    5. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. Epilepsy Currents. Section editor, 2019- present.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Anthony Ritaccio, MD,
    6. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH 1 R13 S International Workshop on Advances in Electrocorticography 07/21/2021NIH U01 Dynamic and Causal function.... 03/21

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. Invention (software for ECoG brain mapping) past 5 yearsg.TEC Graz, Austria

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Elaine C. Wirrell, MD, FRCP(C),
    7. Scientific Advisory Boards:

    1. Encoded TherapeuticsAmicus TherapeuticsAcadia PharmaceuticalsNeurocrine

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. Epilepsia Editorial Board 2010-2012, Journal of Child Neurology Editorial Board 2007-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. Up To Date: Organization of the Epilepsies

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Biomarin

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Dravet Syndrome Foundation 2021 - to support clinical research study

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Katherine C. Nickels, MD,
    8. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. Epilepsy Currents editorial board member 2016-present.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. GW pharmaceuticals research supportZogenix international limited research support

    Research Support, Government Entities:

    1. Pediatric Epilepsy Research Foundation (030-11082016), co-investigator, 2017-2020

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Gregory D. Cascino, MD and
    9. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. Epilepsia (International League Against Epilepsy)-- Associate Editor

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. (1) Mayo Foundation- Mayo Clinic Ventures-High frequency nerve stimulation to treat lower back pain, Nevro, 2013

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. David Burkholder, MD*
    10. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. Department of Neurology (SA, GW, JB, ECW, KCN, GDC, DB), Mayo Clinic, Rochester, MN; Department of Neurology (KN), Mayo Clinic, Scottsdale, AZ; and Department of Neurology (AR), Mayo Clinic, Jacksonville, FL.
  1. Correspondence
    Dr. Agashe shruts_frvr{at}yahoo.com
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