Predictors of Disease Activity and Worsening in Relapsing-Remitting Multiple Sclerosis
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Article Information
- Received December 13, 2021
- Accepted April 11, 2022
- First Published May 12, 2022.
Article Versions
- Previous version (May 12, 2022 - 12:45).
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Author Disclosures
- Yinan Zhang, MD,
- Stacey Cofield, PhD,
- Gary Cutter, PhD,
- Stephen Krieger, MD,
- Jerry S. Wolinsky, MD and
- Fred Lublin, MD
- Yinan Zhang, MD,
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(1) National Multiple Sclerosis Society
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- Stacey Cofield, PhD,
(1) Department of Defense (2) JMP Discovery Summit Advisory Board
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(1) Oxford University Press, reviewer textbook, 2016
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National Multiple Sclerosis Society, NARCOMS
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- Gary Cutter, PhD,
Data and Safety Monitoring Boards: AI Therapeutics, AMO Pharma, Astra-Zeneca, Avexis Pharmaceuticals, Biolinerx, Brainstorm Cell Therapeutics, Bristol Meyers Squibb/Celgene, CSL Behring, Galmed Pharmaceuticals, Green Valley Pharma, Immunic, Mapi Pharmaceuticals LTD, Merck, Merck/Pfizer, Mitsubishi Tanabe Pharma Holdings, Opko Biologics, Novartis, Regeneron, Sanofi-Aventis, Reata Pharmaceuticals, Teva pharmaceuticals, VielaBio Inc, , NHLBI (Protocol Review Committee), NICHD (OPRU oversight committee).
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Multiple Sclerosis Journal: editorial board, (11 yrs); Multiple Sclerosis and Related Disorders: Editorial board; (1 yr);Am journal of the Society of Nephrology. Statistical editor; contributing statistical help (6 yrs); Alzheimer's and Dementia (5) yrs; Neurology Clinical Practice (7yrs recently ended);
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Alexion, Antisense Therapeutics, Biogen, Clinical Trial Solutions LLC, Genzyme, Genentech, GW Pharmaceuticals, Immunic, Klein-Buendel Incorporated, Medimmune/Viela Bio/Horizon Pharmaceuticals, Merck/Serono, Neurogenesis LTD, Novartis, Osmotica Pharmaceuticals, Perception Neurosciences, Protalix Biotherapeutics, Recursion/Cerexis Pharmaceuticals, Regeneron, Reckover Pharmaceuticals, Roche.Therapeutics.
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President of Pythagoras Inc. a consulting company
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P30DK079337 (PI: Agarwal) 08/01/2018 – 07/31/2023 1.77 CM NIH/NIDDK $1,136,699 (total funds) O'Brien Center for Acute Kidney Injury Research Acute kidney injury (AKI) is a major cause for morbidity and mortality in hospitalized patients and is being increasingly recognized as a cause for chronic kidney disease. AKI doubles the length of stay in the hospital, increasing health care resources. The UAB-UCSD O'Brien Center has brought together a team of investigators to serve unmet needs of our investigator base and to fill the gaps in knowledge in the field of AKI and AKI-related research. K23HD091849 (Gerstenecker) 09/12/2018 – 08/31/2023 0 calendar, Co-Mentor NIH/NICHHD $630,875 total costs Investigating the Impact of Cognition on Capacity in Multiple Sclerosis At a time in which increased cognitive ability is needed to make complex financial and medical decisions, people with MS are often experiencing cognitive decline; surprisingly though, research into the ability of people with MS to make complex financial and medical decisions is rare. This study proposes to investigate financial and medical decisional capacity and its clinical and neuroanatomical correlates in people with relapsing- remitting MS and progressive MS. The ultimate value of this research will be to act as a necessary first-step in the development of a targeted capacity rehabilitation program for people diagnosed with MS. K23HL127100 (Lebensburger) 04/01/2015 – 03/31/2021 0 calendar, Mentor NIH/NHLBI $916,445 total costs Chronobiology and Chronopharmacology to Prevent Sickle Cell Nephropathy Hypertension is a known risk factor for stroke in sickle cell disease and in other diseases associated with adverse cardiovascular outcomes. Within the context of a feasibility trial, this proposal will develop vital background data to understand the acceptability of, adherence to, and dosing strategy for losartan prior to conducting a definitive trial for adolescent sickle cell disease patients with abnormal circadian blood pressure. A prospective cohort study will also be conducted to define the relationship of urine and blood biomarkers on the development of abnormal nocturnal blood pressure dipping and kidney injury. PENDING OSP 532909 (Lal) 04/01/2022 – 03/31/2027 0.6 CM NIH $935,194 Optimization of Saturation Targets and Resuscitation Trial (OptiSTART) R34HL157412 (Leesar) 04/01/2021 – 03/31/2024 0.6 CM NIH/NHLBI $668,250 total costs Effects of Crushed Ticagrelor and no Fentanyl Versus Eptifibatide Bolus+Ticagrelor and Fentanyl in Patients with NSTE-ACS Undergoing Early PCI: A randomized Trial (CTEP trial) R21HD104996 (Rogers) 09/01/2021 – 08/31/2023 0.6 CM NIH $408,375 total costs Microbiome as a Novel Mechanism of Exercise Training Effects in Multiple Sclerosis R01HL154109 (Sanders) 04/01/2021 – 03/31/2026 0.6 CM NIH/NHLBI $2,929,087 total costs Dietary Sodium & Potassium and Aortic Stiffness R01TR003741 (Danila) 04/01/2021 – 03/31/2024 0.6 CM NIH/NCATS $2,937,048 total costs Digital Health for Rheumatology Care in COVID19 Era OSP 532630 (Motl) 06/01/2021 – 05/31/2024 0.6 CM Bristol-Myers Squibb Foundation, Inc. $770,799 total costs Exercise Promotion and Outcomes Among African-Americans with Multiple Sclerosis Living in Rural Communities OSP 533051 (Leesar) 04/01/2022 – 03/31/2025 0.6 CM NIH/NHLBI $668,250 total costs Platelet Inhibition with Crushed Ticagrelor versus Eptifibatide Bolus in Patients with Non-ST-Segment Elevation Myocardial Infarction undergoing Ad Hoc PCI with no Opiods R01HD108618 (Taub) 04/01/2022 – 03/31/2024 0.6 CM NIH/NCHHD $1,183,924 total costs A Therapy for Long COVID Brain Fog and Cognitive Impairment U24HL155807 (Aban) 07/01/2021 – 06/30/2027 0.6 CM NIH/NHLBI $1,844,073 total costs 2/2 Video Telehealth Pulmonary Rehabilitation to Reduce Hospital Readmission in Chronic Obstructive Pulmonary Disease (Tele-COPD) R01AG070049 (Taub) 08/01/2021 – 07/31/2025 0.6 CM NIH/NCHHD $2,312,394 total costs Transferring Speed of Processing Gains to Everyday Cognitive Tasks after Stroke R01DK131079 (Novak) 12/01/2021 – 11/30/2026 1.2 CM NIH/NIDDK $3,764,635 total costs Unraveling Clinical and Pathophysiologic Disparities in African Americans with IgA Nephropathy) To address the historic lack of research into this chronic disease in African American patients, we will identify the first large, well-characterized, cohort of African American patients with IgA nephropathy and will assess factors associated with their disease pathogenesis, severity, and progression. 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The MG Registry receives funding from the Myasthenia Gravis Foundation of America
Consortium of MS Centers - Past President - only expenses covered
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- Stephen Krieger, MD,
(1) Yale, DSMB (2) TG Therapeutics, Adjudication Committee (3) EMD Serono, Adjudication Committee
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(1) Biogen - honoraria for non-promotional lectures (2) EMD Serono - honoraria for non-promotional journal club (3) Genentech - honoraria for non-promotional lectures
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(1) Biogen, (2) EMD Serono, (3) Genentech, (4) Novartis, (5) Octave, (6) Genzyme/Sanofi,(7) TG Therapeutics
(1) Biogen, non-promotional speaker, (2) EMD Serono, non-promotional speaker, (3) Genentech, non-promotional speaker
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(1) Biogen, (2) Novartis, (3) BMS
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- Jerry S. Wolinsky, MD and
Compensation for service on steering committees or data monitoring boards for Avotres, Brainstorm Cell Therapeutics, Cleveland Clinic Foundation, EMD Serono, MedDay Pharmaceuticals, Novartis/Sandoz, Roche/Genentech, Sanofi/Genzyme and University of Alabama Birmingham.
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Honoraria, travel support and expenses were provided from Roche for CME related activities.
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US010363245B2; Board of Regents UT System; Methods for treating CNS lesions
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Royalties are received for monoclonal antibodies out-licensed through the University of Texas Health Science Center at Houston to Millipore (Chemicon International) Corporation since 1993.
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- Fred Lublin, MD
Biogen; EMD Serono; Novartis; Teva; Actelion; Sanofi/Genzyme; Acorda; Roche/Genentech; MedImmune/ Viela Bio; Receptos/Celgene; Medday; Atara Biotherapeutics; Mapi Pharma; Innate Immunotherapeutics; Apitope; Orion Biotechnology; Brainstorm Cell Therapeutics; Jazz Pharmaceuticals; GW Pharma; Mylan; Immunic; Population Council; Avotres; Janssen, BMS; Neurogene; Banner Life Sciences; Labcorp; Entelexo Biotherapeutics; Neuralight; SetPoint Medical
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Most, if not all, consulting activity and scientific boards listed above and below involved travel, all before March 2020, that was either paid for directly or reimbursed.
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Same as Advisory Boards
Sanofi Genzyme- non-promotional EMD Serono- non-promotional
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Novartis; Biogen; Sanofi, NMSS, NIH; Brainstorm Cell Therapeutics
1) NIH/NINDS- PI, 2018-2022 2) NIH/NINDS- PI, 2018-2022
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1) National Multiple Sclerosis Society- PI, 2014-2019 2) National Multiple Sclerosis Society- PI 2019-2024
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Stock Options- Avotres; Neuralight
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I have provided occasional expert testimony in various matters
- Department of Neurology (YZ), The Ohio State University Wexner Medical Center, Columbus; Department of Biostatistics (SC, GC), University of Alabama at Birmingham; Department of Neurology (SK, FL), Icahn School of Medicine at Mount Sinai, New York; and Department of Neurology (JSW), McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth).
- Correspondence
Dr. Zhang yinan.zhang{at}osumc.edu
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