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April 2022; 12 (2) Research

Association of Performance on the Financial Capacity Instrument–Short Form With Brain Amyloid Load and Cortical Thickness in Older Adults

Maria Vassilaki, Jeremiah A. Aakre, Walter K. Kremers, Michelle M. Mielke, Yonas E. Geda, Mary M. Machulda, David S. Knopman, Prashanthi Vemuri, Val J. Lowe, Clifford R. Jack, Erik D. Roberson, Adam Gerstenecker, Roy C. Martin, Richard E. Kennedy, Daniel C. Marson, Ronald C. Petersen
First published February 8, 2022, DOI: https://doi.org/10.1212/CPJ.0000000000001157
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Article Information

vol. 12 no. 2 113-124
DOI: 
https://doi.org/10.1212/CPJ.0000000000001157
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
2163-0402
Online ISSN: 
2163-0933
History: 
  • First Published February 8, 2022.

Article Versions

Copyright & Usage: 
© 2022 American Academy of Neurology

Author Disclosures

    1. Maria Vassilaki, MD, PhD, MPH,
    2. Jeremiah A. Aakre, MPH,
    3. Walter K. Kremers, PhD,
    4. Michelle M. Mielke, PhD,
    5. Yonas E. Geda, MD, MSc,
    6. Mary M. Machulda, PhD,
    7. David S. Knopman, MD,
    8. Prashanthi Vemuri, PhD,
    9. Val J. Lowe, MD,
    10. Clifford R. Jack Jr., MD,
    11. Erik D. Roberson, MD, PhD,
    12. Adam Gerstenecker, PhD,
    13. Roy C. Martin, PhD,
    14. Richard E. Kennedy, MD, PhD,
    15. Daniel C. Marson, PhD, JD and
    16. Ronald C. Petersen, MD, PhD
  1. Maria Vassilaki, MD, PhD, MPH,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Journal of Alzheimer's Disease, Associate Editor (2019-present); (2) Frontiers in Neuroscience (Neurodegeneration) Guest Editor for Research Topic collection

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) F. Hoffmann-La Roche Ltd, consultant (payment to my institution), 2021

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) F. Hoffmann-La Roche Ltd; (2) Biogen

    Research Support, Government Entities:

    1. 1) NIA, AG057708, co-Investigator and site PD/PI, 2018- present (2) NIA U01 AG06786, co-Investigator, 2019-present (3) NIA, RF1 AG057181, co-Investigator, 2018-present (4) NIA, R01 AG060920, co-Investigator, 2019 -present (5) NIA, R01 AG068192, co-Investigator, 2020 -present (6) NIA, R01 AG068007, co-Investigator, 2020 -present

    Research Support, Academic Entities:

    1. (1) St. Anne’s University Hospital Brno, International Clinical Research Center, Czech Republic/EU Stock/Stock Options, Medical Equipment & Materials: Spouse (K. Papadakis) and I have stocks in (1) Abbott Laboratories (2020-present); (2) Johnson and Johnson (2018- present); (3) Medtronic (2020-present); and (4) Amgen (2019- present).

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Jeremiah A. Aakre, MPH,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Walter K. Kremers, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 1) AstraZeneca. This is unrelated to this project and there is no conflict of interest. 2) Biogen - Predicting Elevated Brain Amyloid-Beta among Individuals with Cognitive Impairment 3) Roche - Epidemiology of Alzheimer's Disease

    Research Support, Government Entities:

    1. NIA U01AG 06786 (Petersen) Co-I 07/15/2019 - 06/30/2024 Alzheimers Disease Patient Registry NIA P30AG 62677 (Petersen) Core Leader 07/01/2019 - 04/30/2024 Mayo Alzheimer's Disease Research Center NIDDKD RO1DK 90358 (Rule) Co-I 03/15/2016 – 01/31/2022 The Aging Kidney Anatomy Study NIH R01AG 59009 (Petersen) Co-I 09/01/2018 – 06/30/2023 Validation of Online Methods to Predict and Monitor Cognitive Decline NIND R01NS 97495 (Vemuri) Co-I 09/01/2016 – 05/31/2021 Development, Validation, and Application of an Imaging Based CVD Scale NINDS U01NS 100620 (Kantarci) Co-I 09/25/2017 – 08/31/2022 Longitudinal Imaging Biomarkers of Disease Progression in DLB Juvenile Diabetes Research Foundation 2-SRA-2017-503-M-B (Kudva) Co-I 08/01/2017 – 07/31/2019 Harnessing Non-Glucose Feedback Signals for Automatic Glucose Control in Type 1 Diabetes: Confronting Exercise- Safety and Stress-Aware Control NIAMSD R01AR 73147 (Maradit Kremers) Co-I 03/01/2018 – 02/28/2023 Enhance Arthroplasty Research through Electronic Health Records and NLP- enabled Informatics NIDDKD R01DK 120358 (Kudva) Co-I 09/30/2018 – 07/31/2021 Automated Glucose Regulation To Improve Diabetes Control and Outcomes for Pregnant Women with Type 1 Diabetes and Fetus U19AG 63911 (Boeve) Core Leader 09/15/2019 - 06/30/2024 ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) NIDDK R01DK 125252 (Kumar) Co-I 07/09/2020 – 05/31/2023 Fractures and bone disease in living kidney donors R56AG 68206 (Schwarz) 09/15/2020 -08/31/2022 Protecting the Confidentiality of Participants in Studies of Alzheimer's Disease and Related Dementias by Replacing Face Imagery in MRI NIA R01AG 57708 (Vassilaki) Co-I 05/01/2018 – 02/28/2022 Pathways Linking Neuropsychiatric Symptoms with Alzheimer’s Disease Neuroimaging Biomarkers and the Outcome of Incident Mild Cognitive Impairment/Dementia NIA RF1AG 55151 (Mielke) Co-I 05/01/2017 – 04/30/2022 Reproductive Risk Factors for Alzheimer’s Disease Dementia and Pathology NIAMSD R01AG 60950 (Maradit Kremers) Co-I 03/01/2019-11/30/2023 Risk of Cognitive Impairment and Dementia in Total Joint Arthroplasty NIH/NIAMSD R01AR 71338 (Zhao) Co-I 05/01/2017 – 04/30/2022 4DCT Imaging for Improved Diagnosis and Treatment of Wrist Ligament Injuries

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Michelle M. Mielke, PhD,
  5. Yonas E. Geda, MD, MSc,
    6. Scientific Advisory Boards:

    1. Data Safety Monitoring Board.

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. International Clinical Research Center (in part funded by European Union) travel funding for annual advisory board meeting in Brno, Czech republic

    Editorial Boards:

    1. 2013 to present : Member, editorial board of International Psychogeriatrics. 2015 to present. Member, Editorial board of the Journal of Neuropsychiatry and Clinical Neuroscience

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Served as a one time advisory board member for Lundbeck in March of 2017.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 10% research effort (Co-I) funded by ROCHE (ended on December 31 of 2018) Site PI of Green Valley project at Barrow Neurological Institute

    Research Support, Government Entities:

    1. National Institute on Aging/NIH R01AG057708 (Principal investigator).

    Research Support, Academic Entities:

    1. Research Professor, Arizona State University

    Research Support, Foundations and Societies:

    1. 1-Harold Amos Medical Faculty Development Award (RWJ foundation). 2- European Union Regional Development Fund (CZ.1.05/1.1.00/02.0123)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Mary M. Machulda, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Co-Investigator National Institutes of Health; R01 AG 50603-1; 4/2016 – 3/20201 (2) Co-Investigator National Institutes of Health; R01 DC 12519-4; 7/2013 - 06/2018 (3) Co-Investigator Core B - Clinical - Rochester in: Mayo Alzheimer's Disease Research Center. Funded by National Institute on Aging. (P50 AG 16574) 05/01/2014 - 04/30/2019 (4) Co-Investigator - Alzheimer's Disease Patient Registry/Mayo Clinic Study of Aging. Funded by National Institute on Aging. (U01 AG 06786) 07/01/2014 - 06/30- 2019 Mayo Alzheimer's Disease Research Center. Funded by National Institute on Aging. (P50 AG 16574) 05/01/2014 - 04/30/2019 (5) Primary Investigator National Institutes of Health; R01 AG49810-1; 04/01/2016 - 02/28/2021

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. David S. Knopman, MD,
    8. Scientific Advisory Boards:

    1. DIAN study DSMB (Sept 2013 - July 2019; August 2020 - present). Dr. Knopman serves on a Data Safety monitoring Board for a tau therapeutic for Biogen, but receives no personal compensation. He served as a consultant for Samus Therapeutics, Third Rock, Roche, Magellan Health and Alzeca Biosciences but receives no personal compensation. In all of these activities, consulting fees are paid to Dr. Knopman's institution, Mayo Clinic, and he has no control or use of the consulting fees.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Scientific Integrity officer of Neurology.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) A4 clinical trial partially funded by Lilly (site PI) (2) Biogen Alzheimer Study (site PI)

    Research Support, Government Entities:

    1. NIH: R01-AG11378 ongoing, R01 AG41851; P30-AG 62677 (Mayo Alzheimer’s Disease Research Center) ongoing, U01 AG 06786 (Mayo Alzheimer Disease Patient Registry) ongoing. 1U01HL096917 ARIC Dementia Study. AG 037551 Chronic Kidney Disease and Cognitive functioning.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Prashanthi Vemuri, PhD,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Miller Medical Communications Inc.

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. PV is funded by NIH grants (R01 NS097495 and R01 AG056366).

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Val J. Lowe, MD,
    10. Scientific Advisory Boards:

    1. (1) Piramal Imaging (2) Merck Research, INC (3) Bayer Schering Pharma (4) AVID Radiopharmaceuticals (5) Eisai Inc.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) GE Health Care (2) AVID Radiopharmaceuticals (3) Siemens Molecular Imaging

    Research Support, Government Entities:

    1. (1) NIA R01 DC010367-01, CoI, 12/01/09-11/30/14 (2) NIA P50 AG016574-12, Co-PI Project #1, 05/01/09- 04/30/14 (3) NIA R01 AG011378-16, CoI, 06/01/08-05/31/13 (4) NCI R01 R01CA 200551-1 , CoI, 02/01/16-11/30/19 (6) P50 CA102701-07, CoI, 09/01/08-08/31/13 (7) R01 CA125614-04 , CoI,09/26/06-07/31/11 (8) R21 CA123909-02, CoI, 07/01/07-08/01/12 (9) U01AG 06786-30, CoI, 07/01/07-06/30/19 (10) UM1CA 186686-2,CoI, 04/17/14-02/28/19 (11) R01 AG41851-4, CoI, 04/01/12-03/28/17 (12)P50 AG44170-4, CoI, 09/01/12-05/31/17 (13)R01 DC012519-1, CoI, 07/01/13-06/30/18 (14)R01CA 154348-4, CoI, 07/18/14-12/31/16 (15)R21AG 47984-1, PI, 09/01/15-05/31/17 (16)R01NS 89757-1, CoI, 09/15/15-08/31/20

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) MN Partnership for Biotechnology and Medical Genomics (2) Elsie and Marvin Dekelboum Family Foundation (3) Liston Family Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Clifford R. Jack Jr., MD,
    11. Scientific Advisory Boards:

    1. iDMC for Roche no payment involved

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Biogen, Eisai - no payments made

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. Biogen - consultant with no financial compensation Roche - iDSMB with no financial compensation Eisai - speaker with no financial compensation

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. National Institutes of Health: R37-AG011378, RO1- AG041851, U01-AG06786, U01-AG024904, R01-AG37551, R01- AG043392, R01-NS092625, R01 AG50745, UF1 AG32438, R01 AG49704, R01 AG50745, R01 AG40282, R01 AG54491, R01 AG41705, R01 AG51406, R01AG054029, R01 AG55151, R01 AG56366, R01 AG55444, R01 AG46179

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. The Alexander Family Professorship for Alzheimer's disease Research, Mayo Clinic and the GHR Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Erik D. Roberson, MD, PhD,
    12. Scientific Advisory Boards:

    1. (1) Biogen (2) AVROBIO (3) AGTC (4) Lilly

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Brain Research, Senior Editor, 2017-19 (2) J. Neuroscience, Associate Editor, 2014-19 (3) Frontiers in Neuroscience, Associate Editor, 2010- (4) Frontiers in Neurology, Associate Editor, 2018-

    Patents:

    1. (1) Methods and Compositions for Reducing Amyloid beta Levels (2) Agents That Reduce Neuronal Overexcitation, related to tau

    Publishing Royalties:

    1. Amthor, F.R., A.M. Theibert, D.G. Standaert, and E.D. Roberson. (2020). Essentials of Modern Neuroscience. (New York: McGraw-Hill Companies, Inc.).

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. Weston Brain Institute, grant reviews NIH, grant reviews

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Alector, Biogen

    Research Support, Government Entities:

    1. NIH

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. BrightFocus Foundation, Alzheimer's Drug Discovery Foundation, Bluefield Project, Alzheimer's Association

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License fee payments, Technology or Inventions:

    1. (1) Conditional tau knockout mice, Genentech

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  12. Adam Gerstenecker, PhD,
    13. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) HAMMS: Hippocampal internal Architecture and iflaMmatory biomarkers in Multiple Sclerosis, K23HD091849, PI, 09/12/2018 – 08/31/2023. (2) Validation of Online Measures to Predict and Monitor Cognitive Decline, R01AG059009, Co-I, 09/01/18 – 08/31/23. (3) Innate and Adaptive Immunity in Parkinson Disease - Core B: Clinical Research Core, P50NS108675, Co-I, 08/01/18 – 06/30/23.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  13. Roy C. Martin, PhD,
    14. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH/1R01 AG059009, Investigator 2018-2023 NICHD/1R01 HD102723-01A1, Investigator 2021-2026 NINDS-NeuroPace,Inc/1UH3NS109557-01A1, Investigator 2021-2026 NINDS/UH3NS100553, Investigator 2016-2023

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  14. Richard E. Kennedy, MD, PhD,
    15. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Associate Editor, Alzheimer's & Dementia: Translational Research and Clinical Interventions, 2015-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH/NIA, R01 AG060993, PI, 02/15/2019-present (2) NIH/NINDS, R01 NS102257, Biostatistician, 04/01/2018 – present (3) NIH/NINDS, P50NS108675, Biostatistician, 9/30/2018 – present (4) NIH/DHHS, R01AG059009, Biostatistician, 09/01/2018 – present (5) Administration for Community Living, 90DPTB0015, Biostatistician, 09/30/2017-present (6) VA Rehabilitation R&D, VA RRD E1995-R, Biostatistician, 04/01/2016- present (7) NIH/NIA, R01 AG057684, PI, 09/15/2017-present (8) NIH/NINDS, R01 NS107316, Biostatistician, 06/01/2018 – present (9) NIH/NINR, R01 NR017181, Biostatistician, 09/21/2018 – present (10) VA HSR&D, IIR 19-413-2, Biostatistician, 07/01/2020 – present (11) NIH/NIA, RF1 AG072773, Biostatistician, 05/01/2021 – present

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  15. Daniel C. Marson, PhD, JD and
    16. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. Dr. Marson received an initial honoraria upon signing agreement for writing book entitled: (1) Clinical and Forensic Assessment of Financial Capacity; Publisher: Oxford University Press; Expected publication date 2022

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NIH/NIA grant - consultant

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH ADNI-3 grant, AG24904, consultant, (2020-2021) (2) NIH grant AG0059009; consultant through company Financial Cognition Assessments LLC, (2020-2021)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. (1) Inventor of Financial Capacity Instrument and Financial Capacity Instrument--Short Form which are both owned by UAB Research Foundation (2) Contributed to development of e-FCI electronic instrument.

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. Hood law firm, expert witness, 2020-2021 Twenge-Twombley law firm, expert witness, 2018-2021 Friedman law firm, expert witness, 2020-2021 Lee law firm, expert witness, 2020-2021 Efron law firm, expert witness, 2020-2021

  16. Ronald C. Petersen, MD, PhD
    17. Scientific Advisory Boards:

    1. Genentech - DSMB

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. Mild Cognitive Impairment,Oxford University Press, 2003 UpToDate

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Roche, (2) Biogen, (3), Eisai, (4) Merck, (5) Nestle (As noted in question 1, DSMB for Genentech.)

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. National Institute on Aging: U01-AG006786 (PI) (1986-present) P50-AG016574 (PI) (1990-2018) U01-AG024904 (Site PI) (2004-present) U24-AG057437 (Co-PI) (2018-present) P30 AG062677 (PI) (2019 - present) U01NS 125417 (Site PI) (2021 – present)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) GHR Foundation, (2) Mayo Medical Foundation for Education and Research

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. Department of Quantitative Health Sciences (MV, JAA, WKK, M.M. Mielke, RCP), and Department of Neurology (M.M. Mielke, DSK, RCP), Mayo Clinic, Rochester, MN; Department of Neurology (YEG), Barrow Neurological Institute, Phoenix, AZ; Department of Psychiatry and Psychology (M.M. Machulda), and Department of Radiology (PV, VJL, CRJ), Mayo Clinic, Rochester, MN; Department of Neurology (EDR, AG, RCM, DCM), Department of Medicine (REK), and Alzheimer's Disease Center (DCM), University of Alabama at Birmingham.
  1. Correspondence
    Dr. Vassilaki vassilaki.maria{at}mayo.edu
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