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February 2022; 12 (1) Research

Red Desaturation Prevalence and Severity in Healthy Patients

Brian Mikolajczyk, Andrew Ritter, Christian Larson, John Connett, Joshua Olson, Collin McClelland, Michael S. Lee
First published October 30, 2020, DOI: https://doi.org/10.1212/CPJ.0000000000001011
Brian Mikolajczyk
Department of Ophthalmology and Visual Neurosciences (BM, AR, CL, JO, CM, MSL), and Division of Biostatistics (JC), School of Public Health, University of Minnesota, Minneapolis.
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Andrew Ritter
Department of Ophthalmology and Visual Neurosciences (BM, AR, CL, JO, CM, MSL), and Division of Biostatistics (JC), School of Public Health, University of Minnesota, Minneapolis.
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Christian Larson
Department of Ophthalmology and Visual Neurosciences (BM, AR, CL, JO, CM, MSL), and Division of Biostatistics (JC), School of Public Health, University of Minnesota, Minneapolis.
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John Connett
Department of Ophthalmology and Visual Neurosciences (BM, AR, CL, JO, CM, MSL), and Division of Biostatistics (JC), School of Public Health, University of Minnesota, Minneapolis.
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Joshua Olson
Department of Ophthalmology and Visual Neurosciences (BM, AR, CL, JO, CM, MSL), and Division of Biostatistics (JC), School of Public Health, University of Minnesota, Minneapolis.
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Collin McClelland
Department of Ophthalmology and Visual Neurosciences (BM, AR, CL, JO, CM, MSL), and Division of Biostatistics (JC), School of Public Health, University of Minnesota, Minneapolis.
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Michael S. Lee
Department of Ophthalmology and Visual Neurosciences (BM, AR, CL, JO, CM, MSL), and Division of Biostatistics (JC), School of Public Health, University of Minnesota, Minneapolis.
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Citation
Red Desaturation Prevalence and Severity in Healthy Patients
Brian Mikolajczyk, Andrew Ritter, Christian Larson, John Connett, Joshua Olson, Collin McClelland, Michael S. Lee
Neurol Clin Pract Feb 2022, 12 (1) 1-5; DOI: 10.1212/CPJ.0000000000001011

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Abstract

Background and Objectives To determine the percentage of the healthy population that responds asymmetrically to the red desaturation test and to approximate the degree of red desaturation in those individuals. We also sought to elucidate any correlation between demographic variables and red desaturation prevalence and severity.

Methods Adults aged 18 years and older with a normal eye examination, including confrontation fields and best-corrected visual acuity of ≥20/25 in both eyes, were eligible for this prevalence study. Those with objective or subjective afferent visual dysfunction were excluded. A total of 101 eligible participants (68.3% female and 31.7% male; racial/ethnic breakdown of 77.2% White, 11.9% Black, 8.9% Asian, 2.0% N/A; mean (SD) age: 41.5 (15.3) years) were queried whether the monocular perception of redness of a standardized tropicamide bottle cap was the same and to estimate the interocular percentage difference, with 1 eye perceiving the bottle cap at “100% redness.”

Results Twenty-four participants (23.8%) experienced some degree of red desaturation. For these individuals with red desaturation, the average interocular difference was 9.0% (range 2%–25%, 95% confidence interval 6.0%–12.0%). There was no statistical evidence for a relationship between red desaturation and race, sex, or age.

Discussion This study shows that nearly a quarter of healthy patients without apparent optic nerve or macular dysfunction may recognize red desaturation. This deserves consideration when interpreting red desaturation testing in patients suspected to have unilateral optic neuropathy. Further research with larger sample sizes may identify predictors of red desaturation in healthy patients, establish the red desaturation threshold separating pathologic from physiologic phenomena, and assess the repeatability of red desaturation over time in affected individuals.

Footnotes

  • Funding information and disclosures are provided at the end of the article. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp.

  • Received June 3, 2020.
  • Accepted August 18, 2020.
  • © 2021 American Academy of Neurology
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