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August 2021; 11 (4) Research

Biphasic (Subtherapeutic) Levodopa-Induced Respiratory Dysfunction in Parkinson Disease

Veerle A. van de Wetering-van Dongen, Alberto J. Espay, Luca Marsili, Andrea Sturchio, Susanne Ten Holter, Bastiaan R. Bloem, Maarten J. Nijkrake
First published January 25, 2021, DOI: https://doi.org/10.1212/CPJ.0000000000001043
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Article Information

vol. 11 no. 4 e402-e406
DOI: 
https://doi.org/10.1212/CPJ.0000000000001043
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
2163-0402
Online ISSN: 
2163-0933
History: 
  • Received September 2, 2020
  • Accepted November 19, 2020
  • First Published January 25, 2021.

Article Versions

Copyright & Usage: 
© 2021 American Academy of Neurology

Author Disclosures

    1. Veerle A. van de Wetering-van Dongen, MSc,
    2. Alberto J. Espay, MD, MSc,
    3. Luca Marsili, MD, PhD,
    4. Andrea Sturchio, MD,
    5. Susanne Ten Holter, MD,
    6. Bastiaan R. Bloem, MD, PhD and
    7. Maarten J. Nijkrake, PhD
  1. Veerle A. van de Wetering-van Dongen, MSc,
    2. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Alberto J. Espay, MD, MSc,
    3. Scientific Advisory Boards:

    1. Abbvie, Neuroderm, Neurocrine, Amneal, Acadia, Acorda, Kyowa Kirin, Sunovion, Lundbeck, and USWorldMeds.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editorial board member of the Journal of Parkinson’s Disease, European Journal of Neurology, and JAMA Neurology

    Patents:

    1. NONE

    Publishing Royalties:

    1. Lippincott Williams & Wilkins, Cambridge University Press, and Springer.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Abbvie, Neuroderm, Neurocrine, Amneal, Acadia, Acorda, Kyowa Kirin, Sunovion, Lundbeck, and USWorldMeds.

    Speakers' Bureaus:

    1. Acadia, Sunovion, USWorldMeds.

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Michael J Fox Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Luca Marsili, MD, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) The Clinical neurologist International, Editorial Board member, 2018. (2) Frontiers Neurology, Review Editor, 2019 (3) Frontiers Neurology, Guest Associate Editor, 2020 (3) Journal of Clinical Movement Disorders, Editorial Board member, 2020.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Andrea Sturchio, MD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Susanne Ten Holter, MD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Bastiaan R. Bloem, MD, PhD and
    7. Scientific Advisory Boards:

    1. (1) Abbvie (commercial entity); (2) Biogen(commercial entity); (3) UCB (commercial entity);

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) AbbVie (speaker's fee) (commercial entity); (2) Zambon (speaker's fee) (commercial entity); (3) Bial (speaker's fee) (commercial entity); (4) Roche (speaker's fee) (commercial entity) (6) GE Healthcare(speaker's fee) (commercial entity)

    Editorial Boards:

    1. (1) Journal of Parkinson's Disease, co-Editor in Chief (2010-present) (no compensation); (2)Practical Neurology, member editorial board (2018 - presnt)(no compensations) (3)Digital Biomarkers, member editorial board (2017- present (no compensations)

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Zambon (commercial entity) UCB (commercial entity) Abbvie (commercial entity)

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) UCB (commercial entity); (2) AbbVie (commercial entity); (3) Verily (commercial entity).

    Research Support, Government Entities:

    1. (1) A smartphone based, titrated exercise solution for patients with Parkinson's disease in daily life. Grant of ZonMw. Role: project leader. 2019 (2) Proactive and Integrated Management and Empowerment in Parkinson’s Disease (PRIME-PD). Grant of the Gatsby Foundation. Role: project leader. 2018 (3) Vibrating socks: a novel cueing intervention to reduce freezing of gait in Parkinson’s disease. Grant of the Michael J Fox Foundation. Role: project leader. 2018 (4) The PERSPECTIVE study: PERsonalized SPEeCh Therapy for actIVE conversation. Grant of the Michael J Fox Foundation. Role: project leader.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Netherlands Organization for Scientific Research (non- profit entity); (2) Michael J Fox Foundation (non-profit entity); (3) Parkinson Vereniging (non-profit entity); (4) Stichting Parkinson Fonds (non-profit entity); (5) National Parkinson Foundation (non-profit entity); (6) Hersenstichting (non-profit entity) (7) Gatsby foundation (non-profit entity)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Maarten J. Nijkrake, PhD
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. Department of Rehabilitation (VAvdW-vD, MJN), Radboud University Medical Center, Donders Center for Brain, Cognition and Behavior, Nijmegen, the Netherlands; Department of Neurology (AJE, LM, AS), UC Gardner Neuroscience Institute, Gardner Center for Parkinson's Disease and Movement Disorders, University of Cincinnati, OH; and Department of Neurology (STH, BRB), Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Center of Expertise for Parkinson and Movement Disorders, Nijmegen, the Netherlands.
  1. Correspondence
    Ms. van de Wetering-van Dongen veerle.vandewetering-vandongen{at}radboudumc.nl
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