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April 2021; 11 (2) Review

Neurology and the COVID-19 Pandemic

Gathering Data for an Informed Response

View ORCID ProfileBrigit High, View ORCID ProfileAlison M. Hixon, Kenneth L. Tyler, Amanda L. Piquet, Victoria S. Pelak
First published July 13, 2020, DOI: https://doi.org/10.1212/CPJ.0000000000000908
Brigit High
Medical Scientist Training Program (BH, AMH), Rocky Mountain Taste and Smell Center (BH), Department of Neurology (KLT, ALP, VSP), and Department of Ophthalmology (VSP), University of Colorado School of Medicine, Aurora.
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  • ORCID record for Brigit High
Alison M. Hixon
Medical Scientist Training Program (BH, AMH), Rocky Mountain Taste and Smell Center (BH), Department of Neurology (KLT, ALP, VSP), and Department of Ophthalmology (VSP), University of Colorado School of Medicine, Aurora.
PhD
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Kenneth L. Tyler
Medical Scientist Training Program (BH, AMH), Rocky Mountain Taste and Smell Center (BH), Department of Neurology (KLT, ALP, VSP), and Department of Ophthalmology (VSP), University of Colorado School of Medicine, Aurora.
MD
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Amanda L. Piquet
Medical Scientist Training Program (BH, AMH), Rocky Mountain Taste and Smell Center (BH), Department of Neurology (KLT, ALP, VSP), and Department of Ophthalmology (VSP), University of Colorado School of Medicine, Aurora.
MD
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Victoria S. Pelak
Medical Scientist Training Program (BH, AMH), Rocky Mountain Taste and Smell Center (BH), Department of Neurology (KLT, ALP, VSP), and Department of Ophthalmology (VSP), University of Colorado School of Medicine, Aurora.
MD
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Citation
Neurology and the COVID-19 Pandemic
Gathering Data for an Informed Response
Brigit High, Alison M. Hixon, Kenneth L. Tyler, Amanda L. Piquet, Victoria S. Pelak
Neurol Clin Pract Apr 2021, 11 (2) e48-e63; DOI: 10.1212/CPJ.0000000000000908

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Abstract

Purpose of Review The current coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the greatest medical crises faced by our current generation of health care providers. Although much remains to be learned about the pathophysiology of SARS-CoV-2, there is both historical precedent from other coronaviruses and a growing number of case reports and series that point to neurologic consequences of COVID-19.

Recent Findings Olfactory/taste disturbances and increased risk of strokes and encephalopathies have emerged as potential consequences of COVID-19 infection. Evidence regarding whether these sequelae result indirectly from systemic infection or directly from neuroinvasion by SARS-CoV-2 is emerging.

Summary This review summarizes the current understanding of SARS-CoV-2 placed in context with our knowledge of other human coronaviruses. Evidence and data regarding neurologic sequelae of COVID-19 and the neuroinvasive potential of human coronaviruses are provided along with a summary of patient registries of interest to the Neurology community.

Footnotes

  • Funding information and disclosures are provided at the end of the article. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp.

  • ↵* These authors contributed equally to the manuscript.

  • NPub.org/COVID19

  • Received April 30, 2020.
  • Accepted June 18, 2020.
  • © 2020 American Academy of Neurology
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