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December 2020; 10 (6) ResearchOpen Access

Effect of switching from natalizumab to moderate- vs high-efficacy DMT in clinical practice

Carrie M. Hersh, Haleigh Harris, Devon Conway, Le H. Hua
First published February 12, 2020, DOI: https://doi.org/10.1212/CPJ.0000000000000809
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Article Information

vol. 10 no. 6 e53-e65
DOI: 
https://doi.org/10.1212/CPJ.0000000000000809
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
2163-0402
Online ISSN: 
2163-0933
History: 
  • Received September 23, 2019
  • Accepted December 9, 2019
  • First Published February 12, 2020.

Article Versions

Copyright & Usage: 
Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Carrie M. Hersh, DO,
    2. Haleigh Harris, BA,
    3. Devon Conway, MD and
    4. Le H. Hua, MD
  1. Carrie M. Hersh, DO,
    2. Scientific Advisory Boards:

    1. (1) Commercial, Biogen Idec, US Medical MS Franchise Advisory Board (2) Commercial, TEVA, MS Next Generation Advisory Board (3) Commercial, Genentech, US Medical MS Franchise Advisory Board (4) Commercial, Novartis, Siponimod Advisory Board (5) Commercial, EMD Serono, Curious About MS Advisory Board

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) Commercial, Genzyme, speaker/consulting honoraria (2) Commercial, Novartis, speaker/consulting honoraria (3) Commercial, Biogen, speaker/consulting honoraria (4) Commercial, Genentech, speaker/consulting honoraria (5) Commercial, EMD Serono, speaker/consulting honoraria

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Commercial, Genzyme, speaker/consulting honoraria (2) Commercial, Novartis, speaker/consulting honoraria (3) Commercial, Biogen, speaker/consulting honoraria (4) Commercial, Genentech, speaker/consulting honoraria (5) Commercial, EMD Serono, speaker/consulting honoraria

    Speakers' Bureaus:

    1. (1) Commercial, Genzyme, speakers' bureau (2) Commercial, Novartis, speakers' bureau (3) Commercial, Biogen, speakers' bureau

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Commercial, Biogen (2) Commercial, Genentech (3) Commercial, PCORI

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Haleigh Harris, BA,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Devon Conway, MD and
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. I have served as a consultant for Novartis Pharmaceuticals and Tanabe Laboratories.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Novartis Pharmaceuticals

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) National Multiple Sclerosis Society

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Le H. Hua, MD
    5. Scientific Advisory Boards:

    1. (1) Biogen (2) EMD Serono (3) Novartis

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) Biogen, speaker honoraria, funding for travel (2) EMD Serono, speaker honoraria, funding for travel (3) Novartis, speaker honoraria, funding for travel (4) Genzyme, speaker honoraria, funding for travel

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Novartis (2) EMD Serono (3) Biogen (4) Genzyme (5) Genentech (6) Celgene (7) TG Therapeutics

    Speakers' Bureaus:

    1. (1) Genzyme (2) Biogen (3) Novartis (4) EMD Serono

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Eric and Sheila Samson Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. Lou Ruvo Center for Brain Health (CMH, HH, LHH), Cleveland Clinic, Las Vegas, NV; and Mellen Center for Multiple Sclerosis Treatment and Research (DC), Cleveland Clinic, Cleveland, OH.
  1. Correspondence
    Carrie M. Hersh hershc{at}ccf.org
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