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December 2020; 10 (6) ResearchOpen Access

Effect of switching from natalizumab to moderate- vs high-efficacy DMT in clinical practice

Carrie M. Hersh, Haleigh Harris, Devon Conway, Le H. Hua
First published February 12, 2020, DOI: https://doi.org/10.1212/CPJ.0000000000000809
Carrie M. Hersh
Lou Ruvo Center for Brain Health (CMH, HH, LHH), Cleveland Clinic, Las Vegas, NV; and Mellen Center for Multiple Sclerosis Treatment and Research (DC), Cleveland Clinic, Cleveland, OH.
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Haleigh Harris
Lou Ruvo Center for Brain Health (CMH, HH, LHH), Cleveland Clinic, Las Vegas, NV; and Mellen Center for Multiple Sclerosis Treatment and Research (DC), Cleveland Clinic, Cleveland, OH.
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Devon Conway
Lou Ruvo Center for Brain Health (CMH, HH, LHH), Cleveland Clinic, Las Vegas, NV; and Mellen Center for Multiple Sclerosis Treatment and Research (DC), Cleveland Clinic, Cleveland, OH.
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Le H. Hua
Lou Ruvo Center for Brain Health (CMH, HH, LHH), Cleveland Clinic, Las Vegas, NV; and Mellen Center for Multiple Sclerosis Treatment and Research (DC), Cleveland Clinic, Cleveland, OH.
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Citation
Effect of switching from natalizumab to moderate- vs high-efficacy DMT in clinical practice
Carrie M. Hersh, Haleigh Harris, Devon Conway, Le H. Hua
Neurol Clin Pract Dec 2020, 10 (6) e53-e65; DOI: 10.1212/CPJ.0000000000000809

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Article Information

vol. 10 no. 6 e53-e65
DOI: 
https://doi.org/10.1212/CPJ.0000000000000809

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
2163-0402
Online ISSN: 
2163-0933
History: 
  • Received September 23, 2019
  • Accepted December 9, 2019
  • First Published February 12, 2020.

Article Versions

  • Previous version (February 12, 2020 - 12:45).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Carrie M. Hersh, DO,
    2. Haleigh Harris, BA,
    3. Devon Conway, MD and
    4. Le H. Hua, MD
  1. Carrie M. Hersh, DO,
  2. Scientific Advisory Boards:
    1. (1) Commercial, Biogen Idec, US Medical MS Franchise Advisory Board (2) Commercial, TEVA, MS Next Generation Advisory Board (3) Commercial, Genentech, US Medical MS Franchise Advisory Board (4) Commercial, Novartis, Siponimod Advisory Board (5) Commercial, EMD Serono, Curious About MS Advisory Board

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. (1) Commercial, Genzyme, speaker/consulting honoraria (2) Commercial, Novartis, speaker/consulting honoraria (3) Commercial, Biogen, speaker/consulting honoraria (4) Commercial, Genentech, speaker/consulting honoraria (5) Commercial, EMD Serono, speaker/consulting honoraria

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. (1) Commercial, Genzyme, speaker/consulting honoraria (2) Commercial, Novartis, speaker/consulting honoraria (3) Commercial, Biogen, speaker/consulting honoraria (4) Commercial, Genentech, speaker/consulting honoraria (5) Commercial, EMD Serono, speaker/consulting honoraria

    Speakers' Bureaus:
    1. (1) Commercial, Genzyme, speakers' bureau (2) Commercial, Novartis, speakers' bureau (3) Commercial, Biogen, speakers' bureau

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. (1) Commercial, Biogen (2) Commercial, Genentech (3) Commercial, PCORI

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Haleigh Harris, BA,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Devon Conway, MD and
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. I have served as a consultant for Novartis Pharmaceuticals and Tanabe Laboratories.

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. (1) Novartis Pharmaceuticals

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. (1) National Multiple Sclerosis Society

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Le H. Hua, MD
  8. Scientific Advisory Boards:
    1. (1) Biogen (2) EMD Serono (3) Novartis

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. (1) Biogen, speaker honoraria, funding for travel (2) EMD Serono, speaker honoraria, funding for travel (3) Novartis, speaker honoraria, funding for travel (4) Genzyme, speaker honoraria, funding for travel

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. (1) Novartis (2) EMD Serono (3) Biogen (4) Genzyme (5) Genentech (6) Celgene (7) TG Therapeutics

    Speakers' Bureaus:
    1. (1) Genzyme (2) Biogen (3) Novartis (4) EMD Serono

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. Eric and Sheila Samson Foundation

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. Lou Ruvo Center for Brain Health (CMH, HH, LHH), Cleveland Clinic, Las Vegas, NV; and Mellen Center for Multiple Sclerosis Treatment and Research (DC), Cleveland Clinic, Cleveland, OH.
  1. Correspondence
    Carrie M. Hersh hershc{at}ccf.org
View Full Text

Article usage

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Feb 20205000134Highwire
Mar 20203070107Highwire
Apr 2020103036Highwire
May 202078043Highwire
Jun 2020162034Highwire
Jul 202091027Highwire
Aug 2020124043Highwire
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Dec 2020191514138Highwire

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