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June 2020; 10 (3) Research

Technology-enabled assessments to enhance multiple sclerosis clinical care and research

Gabrielle Macaron, Brandon P. Moss, Hong Li, Laura E. Baldassari, Stephen M. Rao, David Schindler, Jay L. Alberts, Malory Weber, Malissa Ayers, François Bethoux, Adrienne Boissy, Desiree Chizmadia, Devon S. Conway, Charlene Fink, Robert J. Fox, Shauna Gales, Bethany Green, Claire Hara-Cleaver, Neal Jordan, Kedar R. Mahajan, Marisa P. McGinley, Deborah M. Miller, Marie Namey, Alexander Rae-Grant, Mary Rensel, Hilary Young, Mary A. Willis, Daniel Ontaneda, Jeffrey A. Cohen, Robert A. Bermel
First published September 6, 2019, DOI: https://doi.org/10.1212/CPJ.0000000000000710
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Article Information

vol. 10 no. 3 222-231
DOI: 
https://doi.org/10.1212/CPJ.0000000000000710
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
2163-0402
Online ISSN: 
2163-0933
History: 
  • Received March 13, 2019
  • Accepted June 19, 2019
  • First Published September 6, 2019.

Article Versions

Copyright & Usage: 
© 2019 American Academy of Neurology

Author Disclosures

    1. Gabrielle Macaron, MD,
    2. Brandon P. Moss, MD,
    3. Hong Li,
    4. Laura E. Baldassari, MD,
    5. Stephen M. Rao, PhD,
    6. David Schindler, BS,
    7. Jay L. Alberts, PhD,
    8. Malory Weber,
    9. Malissa Ayers, PA-C,
    10. François Bethoux, MD,
    11. Adrienne Boissy, MD,
    12. Desiree Chizmadia, CNP,
    13. Devon S. Conway, MD,
    14. Charlene Fink, CNS-BC,
    15. Robert J. Fox, MD,
    16. Shauna Gales, PA-C,
    17. Bethany Green, CNP,
    18. Claire Hara-Cleaver, CNP,
    19. Neal Jordan,
    20. Kedar R. Mahajan, PhD,
    21. Marisa P. McGinley, DO,
    22. Deborah M. Miller, PhD,
    23. Marie Namey, CNS-BC,
    24. Alexander Rae-Grant, MD,
    25. Mary Rensel, MD,
    26. Hilary Young, PA-C,
    27. Mary A. Willis, MD,
    28. Daniel Ontaneda, MD,
    29. Jeffrey A. Cohen, MD and
    30. Robert A. Bermel, MD
  1. Gabrielle Macaron, MD,
    2. Scientific Advisory Boards:

    1. Scientific Advisory board for Genentech

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen

    Research Support, Commercial Entities:

    1. I have received fellowship funding from Biogen (Biogen Fellowship Grant 6873-P-FEL) from November 2017 to October 2018.

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. I am currently receiving fellowship funding from the National Multiple Sclerosis Society (National Multiple Sclerosis Society Institutional Clinician Training Award ICT 0002) since November 2018.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Brandon P. Moss, MD,
    3. Scientific Advisory Boards:

    1. (1) Genentech

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. (1) Sanofi Genzyme

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. (1) Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen. Stock/Stock Options, Medical Equipment & Materials: (1) Pfizer, 1 year

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Hong Li,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Laura E. Baldassari, MD,
    5. Scientific Advisory Boards:

    1. (1) Teva

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. (1) Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) National Multiple Sclerosis Society (Grant FP-1606- 24540)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Stephen M. Rao, PhD,
    6. Scientific Advisory Boards:

    1. Data safety monitoring board, University of Florida

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editor-in-Chief, Journal of the International Neuropsychological Society Associate Editor, American Psychologist

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Received consulting fees from University of Florida.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen.

    Research Support, Commercial Entities:

    1. Biogen

    Research Support, Government Entities:

    1. NIH

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. Qr8 Health, Inc.

    License fee payments, Technology or Inventions:

    1. Cleveland Clinic

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. David Schindler, BS,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. Various patents related to the MSPT and contained assessment modules.

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Qr8 Health, Director of Product Development, 2 years

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen. Stock/Stock Options, Medical Equipment & Materials: Qr8 Health, 2 years

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Jay L. Alberts, PhD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. Troop Readiness Evaluation with Augmented Reality Return-to-Duty (READY) System NIPA: Non-Invasive Intracranial Pressure Assessment AR/VR in Neurological Care Smart Phone Enabled Assessment of Timed Up and Go Test Gait and Balance Smart Footwear

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen.

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Malory Weber,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen.

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Malissa Ayers, PA-C,
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1)Genzyme, honoraria (2)Biogen, honoraria (3)Novartis, honoraria

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. (1)Genzyme (2)Biogen (3) Novartis

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. François Bethoux, MD,
    11. Scientific Advisory Boards:

    1. (1) Ipsen. (2) GW Pharma

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. (1) TeamWorks

    Editorial Boards:

    1. (1) International Journal of MS Care, editorial board member, 2008-present. (2) US Neurology, Multiple Sclerosis section editor, 2010-present.

    Patents:

    1. (1) Multiple Sclerosis Performance Test

    Publishing Royalties:

    1. (1) Multiple Sclerosis and Related Disorders: Diagnosis, Medical Management, and Rehabilitation, Demos Publishing, 2013. (2) Multiple Sclerosis and Related Disorders: Diagnosis, Medical Management, and Rehabilitation. 2nd edition, Demos Publishing, 2018

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Abide Pharmaceuticals. (2) MedRhythms

    Speakers' Bureaus:

    1. (1) Biogen

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 1) Biogen. (2) Adamas Pharmaceuticals. (3) Acorda Therapeutics

    Research Support, Government Entities:

    1. (1)NIH - 1UH3NS100543-01, co-investigator, 2016-2021

    Research Support, Academic Entities:

    1. 1) Cleveland Clinic Foundation

    Research Support, Foundations and Societies:

    1. (1) Patient-Centered Outcomes Research Institute. (2) Consortium of MS Centers. (3) National Multiple Sclerosis Society

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. Multiple Sclerosis Performance Test, Biogen

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Adrienne Boissy, MD,
    12. Scientific Advisory Boards:

    1. Immediate family member on: (1) Blockade Medical (2) Codman Neurovascular (3) Medtronic (4) Stryker (5) Teladoc (6) Nervive (7) Perflow Ltd

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Journal of Patient Experience 2015-2019

    Patents:

    1. NONE

    Publishing Royalties:

    1. (1)An immediate family member received publishing royalties from Endovascular Tachniques in the Management of Cerebrovascular Disease, Informa Healthcare 2008. (2) Communication the Cleveland clinic Way, McGraw Hill

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. An immediate family member has consulted for: 1)Possis 2)Cohen Group 3)MedyMatch

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 health and Biogen

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. Immediate family member and self : (1) Blockade Medical Immediate Family Member: (1) Cordinus Vascular Robotics

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. Immediate family member: Medhana MEdical LLC Stock/Stock Options, Medical Equipment & Materials: Dr Boissy and an immediate family member: (1) EV3, 2009 (2)Chestnut Medical Technologies, 2009 (3) Neurvana

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  12. Desiree Chizmadia, CNP,
    13. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen.

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  13. Devon S. Conway, MD,
    14. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. I have served as a consultant for Novartis Pharmaceuticals and Tanabe Laboratories.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Novartis Pharmaceuticals

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) National Multiple Sclerosis Society

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  14. Charlene Fink, CNS-BC,
    15. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. did patient speaker engagements for Teva Pharmaceuticals and Sanofi Genzyme

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen.

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  15. Robert J. Fox, MD,
    16. Scientific Advisory Boards:

    1. Actelion, Biogen Idec, Immunic, Novartis

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editorial Board, Neurology Editorial Board, Multiple Sclerosis Journal

    Patents:

    1. NONE

    Publishing Royalties:

    1. Multiple Sclerosis and Related Disorders, Demos Medical, 2019

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Actelion, Biogen, EMD Serono, Genentech, Novartis, Teva

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen.

    Research Support, Commercial Entities:

    1. Research grants from Novartis and Biogen

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. National MS Society, RG 4778-A-6, 2013-2019; NIH 1U01NS082329-01A1, 2013-2019; Consortium of MS Centers

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  16. Shauna Gales, PA-C,
    17. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  17. Bethany Green, CNP,
    18. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  18. Claire Hara-Cleaver, CNP,
    19. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Commercial Advisor for Novartis, Genentech and Biogen

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. I currently work for Biogen, the paper was submitted while I was still employed by Cleveland Clinic Mellon Center as a Nurse Practitioner

    Consultancies:

    1. Advisor for Novartis, Genentech, Biogen

    Speakers' Bureaus:

    1. Advisor for Novartis, Genentech, Biogen

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  19. Neal Jordan,
    20. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Epic Systems Corporation, Consultant, 12 years

    Consultancies:

    1. IT Consultant for the Cleveland Clinic, IT Consultant for Epic Systems Corporation

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Epic Systems Corporation

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  20. Kedar R. Mahajan, PhD,
    21. Scientific Advisory Boards:

    1. Dr. Mahajan served on a scientific advisory board for Sanofi Genzyme and Genentech.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. Dr. Mahajan received personal fees for an unbranded round table discussion with Sanofi Genzyme.

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen.

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Dr. Mahajan has received research support from NMSS-ABF (FAN- 1507-05605) and NIH/NINDS (1K23NS109328).

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  21. Marisa P. McGinley, DO,
    22. Scientific Advisory Boards:

    1. 1) Genentech 2) Genzyme

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen.

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1) National Multiple Sclerosis Society

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  22. Deborah M. Miller, PhD,
    23. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Associate Editor for Quality of Life Research (2009 - 2011) Associate Editor for Journal of Rehabilitation Research and Development (2009 - 2011)

    Patents:

    1. Deborah Miller shares rights to intellectual property underlying the Multiple Sclerosis Performance Test, currently licensed to Qr8 Health and Biogen

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultant to Can Do MS (2009 - 2019)

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. Invited speaker for the Consortium of Multiple Sclerosis Centers.

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  23. Marie Namey, CNS-BC,
    24. Scientific Advisory Boards:

    1. (1) Biogen, (2) Sanofi Genzyme, (3) Genentech, (4) Celgene

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. (1) Biogen, (2) Sanofi Genzyme, (3) Genentech

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  24. Alexander Rae-Grant, MD,
    25. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Neurology, Evidence Review Team, 2011-2018

    Patents:

    1. NONE

    Publishing Royalties:

    1. Handbook of Multiple Sclerosis, Springer Healthcare, 2010 Comprehensive review of clinical neurology, Wolters Kluwer, 2012. 5 minute consult in neurology, Wolters Klower, 2012 Comprehensive review of clinical neurology second edition, LWW, 2016. Ultimate review of neurology DEMOS 2016 Multiple Sclerosis and Related disorders, DEMOS, 2014

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. I am neurology editor for DynaMed an online point of care evidence based tool for clinicians. This is a 50% time commitment. There is no pharma funding (all subscription services) and not related to this paper.

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  25. Mary Rensel, MD,
    26. Scientific Advisory Boards:

    1. 1. Serono

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Biogen, Honoraria for speaking engagements Novartis, Honoraria for speaking engagements Teva, Honoraria for speaking engagements Genzyme, Honoraria for speaking engagements

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. Biogen, Honoraria for speaking engagements Novartis, Honoraria for speaking engagements Teva, Honoraria for speaking engagements Genzyme, Honoraria for speaking engagements, Celgene- advisory board

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen

    Research Support, Commercial Entities:

    1. Medimmune Genzyme,educational grant

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. National Multiple Sclerosis Society

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  26. Hilary Young, PA-C,
    27. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property contained within the MSPT, currently licensed to Qr8 Health and Biogen.

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  27. Mary A. Willis, MD,
    28. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. International Journal of MS Care, member of editorial board, 7 years

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. Genzyme, Biogen, Novartis, Ipsen

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  28. Daniel Ontaneda, MD,
    29. Scientific Advisory Boards:

    1. 1) Genzyme, 2) Genentech, 3) Biogen Idec, 4)Novartis

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Biogen Idec, Genzyme, Genentech, Merck, Novartis

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 1) Genzyme, 2) Novartis, 3) Genentech

    Research Support, Government Entities:

    1. NIH R35NS097303 Co-investigator 2017-2018

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NMSS PCORI Race to Erase Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  29. Jeffrey A. Cohen, MD and
    30. Scientific Advisory Boards:

    1. Alkermes 4/9/18 - Consulting Biogen 6/4/18 - Consulting Convelo 2/28/18, 3/1/18, 4/2/18, 4/27/18, 5/31/18, 6/28/18, 7/31/18, 8/28/18, 10/2/18, 10/30/18, 11/28/18, 12/24/18, 1/29/19, 2/26/19, 3/26/19 - Consulting EMD Serono 12/13/17, 6/28/18 - Consulting ERT 5/9/18 - Consulting Gossamer Bio 6/27/18 - Consulting Novartis 6/27/17, 1/27/18, 4/23/18, 4/24/18 - Consulting ProValuate 6/11/18 - consulting

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Mylan 10/26/17, 5/17/18 - speaker honorarium Synthon 4/5/18 - speaker honorarium

    Editorial Boards:

    1. 2019-present - Co-Editor Multiple Sclerosis Journal

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  30. Robert A. Bermel, MD
    31. Scientific Advisory Boards:

    1. Biogen, Genentech, Genzyme, Novartis

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Biogen, Genzyme, Genentech, Novartis, Roche

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. Cleveland Clinic shares rights to intellectual property underlying the MSPT, currently licensed to Qr8 Health and Biogen.

    Research Support, Commercial Entities:

    1. Novartis, Genentech, Biogen

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. Robert Bermel shares rights to intellectual property underlying the MSPT, currently licensed to Qr8 Health and Biogen

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. Mellen Center for Multiple Sclerosis (GM, BPM, LEB, MW, MA, FB, AB, DC, DSC, CF, RJF, SG, BG, CH-C, KRM, MPM, DMM, MN, AR-G, MR, HY, MAW, DO, JAC, RAB), Neurological Institute, Cleveland Clinic Foundation; Department of Quantitative Health Sciences (HL), Cleveland Clinic; Schey Center for Cognitive Neuroimaging (SMR), Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic Foundation; Department of Biomedical Engineering (DS, JLA), Lerner Research Institute, Cleveland Clinic Foundation, OH; and Epic Systems Corporation (NJ), Verona, WI.
  1. Correspondence
    Dr. Bermel bermelr{at}ccf.org
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