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December 01, 2017; 7 (6) Case

Small fiber neuropathy presenting during the antecedent period of undifferentiated arthritis prior to rheumatoid arthritis

Julius Birnbaum
First published October 24, 2017, DOI: https://doi.org/10.1212/CPJ.0000000000000400
Julius Birnbaum
Departments of Neurology and Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.
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Small fiber neuropathy presenting during the antecedent period of undifferentiated arthritis prior to rheumatoid arthritis
Julius Birnbaum
Neurology: Clinical Practice Dec 2017, 7 (6) e47-e50; DOI: 10.1212/CPJ.0000000000000400

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In contrast to Sjögren syndrome (SS),1 small fiber neuropathies (SFN) associated with rheumatoid arthritis (RA) have been sparsely reported.2 Furthermore, many patients with RA pass through an antecedent period termed undifferentiated arthritis (UA),3 in which they may experience an inflammatory arthritis not satisfying criteria for RA or another inflammatory syndrome. SFN may be a rare complication occurring during this presaging period of UA. Yet this possibility is relevant, given that SFN may antedate systemic manifestations of other rheumatic diseases (i.e., SS).1 We report an unusual case of SFN initially developing in a patient with UA, who ultimately develops RA.

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  • Funding information and disclosures are provided at the end of the article. Full disclosure form information provided by the author is available with the full text of this article at Neurology.org/cp.

  • Received April 28, 2017.
  • Accepted July 19, 2017.
  • © 2017 American Academy of Neurology
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Neurology: Clinical Practice |  Print ISSN: 2163-0402
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